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Yet, most research is undermined by low interpretability and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Combining statistical and machine learning analyses of natural speech data, we aimed to discriminate ADD patients from healthy controls (HCs) based on automated measures of domains typically affected in ADD: semantic granularity (coarseness of concepts) and ongoing semantic variability (conceptual closeness of successive words). To test for specificity, we replicated the analyses on Parkinson's disease (PD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relative to controls, ADD (but not PD) patients exhibited significant differences in both measures. Also, these features robustly discriminated between ADD patients and HC, while yielding near\u2010chance classification between PD patients and HCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Automated discourse\u2010level semantic analyses can reveal objective, interpretable, and specific markers of ADD, bridging well\u2010established neuropsychological targets with digital assessment tools.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12276","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T07:01:23Z","timestamp":1642143683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Automated text\u2010level semantic markers of Alzheimer's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Camila","family":"Sanz","sequence":"first","affiliation":[{"name":"Departamento de F\u00edsica Universidad de Buenos Aires and Instituto de F\u00edsica de Buenos Aires (IFIBA\u2010CONICET) Pabell\u00f3n I Ciudad Universitaria (1428) CABA  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Facundo","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Applied Artificial Intelligence Lab (ICC\u2010CONICET) Pabell\u00f3n I Ciudad Universitaria (1428) CABA  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Slachevsky","sequence":"additional","affiliation":[{"name":"Memory and Neuropsychiatric Clinic, Neurology Department, Hospital del Salvador (7500000), SSMO &amp; Faculty of Medicine (8380000) University of Chile  Santiago Chile"},{"name":"Center for Brain Health and Metabolism (GERO) (7500922)  Santiago Chile"},{"name":"Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department, Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile (7500922) University of Chile  Santiago Chile"},{"name":"Servicio de Neurolog\u00eda, Departamento de Medicina Cl\u00ednica Alemana\u2010Universidad del Desarrollo (7550000)  Santiago Chile"},{"name":"East Neuroscience Department, Faculty of Medicine (7650567) University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Forno","sequence":"additional","affiliation":[{"name":"Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department, Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile (7500922) University of Chile  Santiago Chile"},{"name":"School of Psychology Universidad de los Andes (7550000)  Santiago Chile"},{"name":"Alzheimer's and other cognitive disorders group Institute of Neurosciences (08035) University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Gorno Tempini","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology (94143) University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roque","family":"Villagra","sequence":"additional","affiliation":[{"name":"Center for Brain Health and Metabolism (GERO) (7500922)  Santiago Chile"},{"name":"East Neuroscience Department, Faculty of Medicine (7650567) University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) (7550000) Universidad Adolfo Ib\u00e1\u00f1ez  Santiago Chile"},{"name":"Cognitive Neuroscience Center (1644) Universidad de San Andr\u00e9s  Buenos Aires Argentina"},{"name":"National Scientific and Technical Research Council (1425)  Buenos Aires Argentina"},{"name":"Global Brain Health Institute (94143) University of California\u2010San Francisco, San Francisco, California, USA; 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