{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:43:07Z","timestamp":1778902987921,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":90,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["98480"],"award-info":[{"award-number":["98480"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction<\/jats:bold>: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. <jats:bold>Methods<\/jats:bold>: In a longitudinal cohort, we investigate whether amyloid deposition at time point 1 (TP1) could predict cortical thickness change at time point 2 (TP2). The association between tau burden and cortical thickness was also examined at time point 3 (TP3). <jats:bold>Results<\/jats:bold>: Between TP1 and TP2 there was pronounced cortical thinning in temporo\u2010parietal cortices and cortical thickening in the frontal cortex. Baseline amyloid burden was strongly associated to cortical thinning progression, especially in the temporo\u2010parietal regions. At TP3, tau deposition negatively correlated with cortical atrophy in regions where tau usually accumulates at later Braak stages. <jats:bold>Discussion<\/jats:bold>: A higher amount of amyloid accumulation triggers a cascade of changes of disease\u2010causing processes that eventually lead to dementia. As expected, we found that regions where tau usually accumulates were those also displaying high levels of cortical atrophy.<\/jats:p>","DOI":"10.1002\/dad2.12288","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T10:44:31Z","timestamp":1648809871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-6787","authenticated-orcid":false,"given":"Concepcion","family":"Padilla","sequence":"first","affiliation":[{"name":"Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"Memory Unit and Biomedical Research Institute Sant Pau (IIB Sant Pau), Neurology Department Santa Creu and Sant Pau Hospital  Barcelona 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