{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:24:15Z","timestamp":1792434255420,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":86,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Physical inactivity and female sex are independently associated with increased Alzheimer's disease (AD) lifetime risk. This study investigates the possible interactions between sex and physical activity on neuroimaging biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 134 cognitively unimpaired older adults (\u226565 years, 82 women) from the Age\u2010Well randomized controlled trial (baseline data), we investigated the association between physical activity and multimodal neuroimaging (gray matter volume, glucose metabolism, perfusion, and amyloid burden), and how sex modulates these associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anterior cingulate cortex volume was independently associated with sex and physical activity. Sex and physical activity interacted on perfusion and amyloid deposition in medial parietal regions, such that physical activity was related to perfusion only in women, and to amyloid burden only in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Physical activity has both sex\u2010dependent and sex\u2010independent associations with brain integrity. Our findings highlight partly distinct reserve mechanisms in men and women, which might in turn influence their risk of AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Sex and physical activity have been linked to Alzheimer's disease (AD) progression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The association of sex and physical activity with brain health is partly independent.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Different reserve mechanisms exist in men and women.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12302","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T16:18:24Z","timestamp":1648484304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Men and women show partly distinct effects of physical activity on brain integrity"],"prefix":"10.1002","volume":"14","author":[{"given":"Julie","family":"Gonneaud","sequence":"first","affiliation":[{"name":"Normandie Universit\u00e9 Universit\u00e9 de Caen Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1237 \"Physiopathology and Imaging of Neurological Disorders,\u201d Institut Blood and Brain@ Caen\u2010Normandie GIP Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Moreau","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9 Universit\u00e9 de Caen Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1237 \"Physiopathology and Imaging of Neurological Disorders,\u201d Institut Blood and Brain@ Caen\u2010Normandie GIP Cyceron  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Felisatti","sequence":"additional","affiliation":[{"name":"Normandie Universit\u00e9 Universit\u00e9 de 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