{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T20:57:27Z","timestamp":1786913847993,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":348,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG0518440"],"award-info":[{"award-number":["AG0518440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG051848"],"award-info":[{"award-number":["AG051848"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG058533"],"award-info":[{"award-number":["AG058533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG062429"],"award-info":[{"award-number":["AG062429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99\/R00\u00a0AG070390"],"award-info":[{"award-number":["K99\/R00\u00a0AG070390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG072946"],"award-info":[{"award-number":["AG072946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG061111"],"award-info":[{"award-number":["AG061111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS118584"],"award-info":[{"award-number":["NS118584"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG062418"],"award-info":[{"award-number":["AG062418"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Limbic predominant age related TDP\u201043 encephalopathy neuropathological change (LATE\u2010NC) is a recently characterized brain disease that mimics Alzheimer's disease (AD) clinically. To date, LATE\u2010NC is difficult to diagnose antemortem using clinical information or biomarkers. Recent studies suggest concentrations of extracellular vesicle (EVs) protein cargo derived from neuronal and glial cells may serve as useful diagnostic biomarkers for AD and other neurodegenerative diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TDP\u201043 was evaluated in neuronal (NDEVs), astrocyte (ADEVs), and microglial derived extracellular vesicles (MDEVs). EV preparations were isolated from the plasma of research subjects with autopsy\u2010confirmed diagnoses, including many with LATE (n\u00a0=\u00a022). Quantified TDP\u201043 concentrations were compared to the cohort that included healthy controls, mild cognitively impairment (MCI), and AD dementia with diagnoses other than LATE\u2010NC (n\u00a0=\u00a042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TDP\u201043 was significantly elevated in plasma ADEVs derived from autopsy confirmed LATE\u2010NC subjects, with or without comorbid AD pathology. Measurable levels of TDP\u201043 were also detected in EV\u2010depleted plasma; however, TDP\u201043 levels were not significantly different between persons with and without eventual autopsy confirmed LATE\u2010NC. No correlation was observed between EV TDP\u201043 levels with cognition\u2010based variables, sex, and APOE carrier status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Blood\u2010based EVs, specifically measuring TDP\u201043 accumulation in ADEVs, may serve as a potential diagnostic tool to rapidly identify subjects who are currently living with LATE\u2010NC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12365","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T07:00:20Z","timestamp":1671087620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of blood\u2010based, extracellular vesicles as biomarkers for aging\u2010related TDP\u201043 pathology"],"prefix":"10.1002","volume":"14","author":[{"given":"Charisse N.","family":"Winston","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Sukreet","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia M.\u2010Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Wilcock","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  La Jolla California USA"},{"name":"VA San Diego Healthcare System  La Jolla California 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