{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:42:40Z","timestamp":1761514960118,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T00:00:00Z","timestamp":1670112000000},"content-version":"vor","delay-in-days":337,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fatty acid\u2013binding protein 3 (FABP3) is a biomarker of neuronal membrane disruption, associated with lipid dyshomeostasis\u2014a notable Alzheimer's disease (AD) pathophysiological change. We assessed the association of cerebrospinal fluid (CSF) FABP3 levels with brain amyloidosis and the likelihood\/risk of developing amyloidopathy in cognitively healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FABP3 levels were measured in CSF samples of cognitively healthy participants, &gt; 60 years of age (<jats:italic>n<\/jats:italic> = 142), from the Australian Imaging, Biomarkers &amp; Lifestyle Flagship Study of Ageing (AIBL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FABP3 levels were positively associated with baseline brain amyloid beta (A\u03b2) load as measured by standardized uptake value ratio (SUVR, standardized <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.22, <jats:italic>P =<\/jats:italic> .009) and predicted the change in brain A\u03b2 load (standardized <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.32, <jats:italic>P =<\/jats:italic> .004). Higher levels of CSF FABP3 (above median) were associated with a likelihood of amyloidopathy (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.12 to 4.65, <jats:italic>P =<\/jats:italic> .023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results support inclusion of CSF FABP3 as a biomarker in risk\u2010prediction models of AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12377","type":"journal-article","created":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T23:49:03Z","timestamp":1670197743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebrospinal fluid levels of fatty acid\u2013binding protein 3 are associated with likelihood of amyloidopathy in cognitively healthy individuals"],"prefix":"10.1002","volume":"14","author":[{"given":"Kunal","family":"Dhiman","sequence":"first","affiliation":[{"name":"IMPACT \u2013 The Institute for Mental and Physical Health and Clinical Translation School of Medicine Deakin University  Geelong Victoria Australia"},{"name":"Western Health Partnership School of Nursing and Midwifery (Centre for Quality and Patient Safety Research in the Institute of Health Transformation) Faculty of Health Deakin University  Melbourne Victoria Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Molecular Imaging &amp; Therapy and Centre for PET Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medicine The University of Melbourne  Melbourne Victoria 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Australia"},{"name":"The Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging &amp; Therapy and Centre for PET Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medicine The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ames","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute  Parkville Victoria Australia"},{"name":"Academic Unit for Psychiatry of Old age St. George's Hospital The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"},{"name":"UK Dementia Research 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