{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:03:02Z","timestamp":1792598582311,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH\u2010000500\u2010001"],"award-info":[{"award-number":["MOH\u2010000500\u2010001"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH\u2010000707\u201001"],"award-info":[{"award-number":["MOH\u2010000707\u201001"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSA\u2010SI\/007\/2016"],"award-info":[{"award-number":["NMRC\/CSA\u2010SI\/007\/2016"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CG\/M006\/2017"],"award-info":[{"award-number":["NMRC\/CG\/M006\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CG\/013\/2013"],"award-info":[{"award-number":["NMRC\/CG\/013\/2013"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CG\/NUHS\/2010"],"award-info":[{"award-number":["NMRC\/CG\/NUHS\/2010"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Plasma neurofilament light chain (NfL) is a potential biomarker for neurodegeneration in Alzheimer's disease (AD), ischemic stroke, and non\u2010dementia cohorts with cerebral small vessel disease (CSVD). However, studies of AD in populations with high prevalence of concomitant CSVD to evaluate associations of brain atrophy, CSVD, and amyloid beta (A\u03b2) burden on plasma NfL are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Associations were tested between plasma NfL and brain A\u03b2, medial temporal lobe atrophy (MTA) as well as neuroimaging features of CSVD, including white matter hyperintensities (WMH), lacunes, and cerebral microbleeds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that participants with either MTA (defined as MTA score \u22652; neurodegeneration [N]+WMH\u2212) or WMH (cut\u2010off for log\u2010transformed WMH volume at 50th percentile; N\u2212WMH+) manifested increased plasma NfL levels. Participants with both pathologies (N+WMH+) showed the highest NfL compared to N+WMH\u2212, N\u2212WMH+, and N\u2212WMH\u2212 individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Plasma NfL has potential utility in stratifying individual and combined contributions of AD pathology and CSVD to cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.12396","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:24:26Z","timestamp":1679876666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Brain atrophy and white matter hyperintensities are independently associated with plasma neurofilament light chain in an Asian cohort of cognitively impaired patients with concomitant cerebral small vessel disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Joyce R.","family":"Chong","sequence":"first","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Kent Ridge Singapore"},{"name":"Memory, Aging and Cognition Centre National University Health Systems  Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Hilal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Kent Ridge Singapore"},{"name":"Memory, Aging and Cognition Centre National University Health Systems  Kent Ridge Singapore"},{"name":"Saw Swee Hock School of Public Health National University of Singapore and National University Health System  Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg  Gothenburg Sweden"},{"name":"King's College London Institute of Psychiatry Psychology and Neuroscience Maurice Wohl Institute Clinical Neuroscience Institute  London UK"},{"name":"NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthonin","family":"Reilhac","sequence":"additional","affiliation":[{"name":"Clinical Imaging Research Centre Yong Loo Lin School of Medicine National University of Singapore  Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Vrooman","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00f6ll","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Hong Kong Center for Neurodegenerative Diseases the Hong Kong University of Science and Technology Hong Kong Science Park Shatin New Territories  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Kent Ridge Singapore"},{"name":"Memory, Aging and Cognition Centre National University Health Systems  Kent Ridge Singapore"},{"name":"Department of Psychological Medicine Yong Loo Lin School of Medicine National University of Singapore  Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell K. P.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Kent Ridge Singapore"},{"name":"Memory, Aging and Cognition Centre National University Health Systems  Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200068"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0676-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt188"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-021-00566-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00463-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000200459"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205010666131119234308"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12495"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12270"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90746-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327370"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.04.014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.6117"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.0765"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23620-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1242"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02808.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366119"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.02565"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.02845"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030302"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200022"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004645"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18775215"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026410"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325681"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12332"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_30_1","first-page":"51","article-title":"Apolipoprotein \u025b4 is associated with dementia and cognitive impairment predominantly due to Alzheimer's disease and not with vascular cognitive impairment: a Singapore\u2010based cohort","author":"Chai YL","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.12.010"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep32573"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12358"},{"key":"e_1_2_8_34_1","volume-title":"RStudio: Integrated Development Environment for R. RStudio","author":"RStudio Team","year":"2022"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v098.i11"},{"key":"e_1_2_8_36_1","unstructured":"ChristianT KapsnerLA.cutpointr: Bootstrapping.2022.https:\/\/cran.r\u2010project.org\/web\/packages\/cutpointr\/vignettes\/cutpointr_bootstrapping.html"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13389"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003154"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308426"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00506-8"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006282"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09477-9"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200004"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12404"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024941"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05557-6"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-320106"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.08.002"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00682-7"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200755"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69113-7"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.11.017"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa098"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.12396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:25:57Z","timestamp":1760361957000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.12396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/dad2.12396"],"URL":"https:\/\/doi.org\/10.1002\/dad2.12396","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12396"}}