{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:46:32Z","timestamp":1793490392588,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Continuous measures of amyloid burden as measured by positron emission tomography (PET) are being used increasingly to stage Alzheimer's disease (AD). This study examined whether cerebrospinal fluid (CSF) and plasma amyloid beta (A\u03b2)42\/A\u03b240 could predict continuous values for amyloid PET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CSF A\u03b242 and A\u03b240 were measured with automated immunoassays. Plasma A\u03b242 and A\u03b240 were measured with an immunoprecipitation\u2013mass spectrometry assay. Amyloid PET was performed with Pittsburgh compound B (PiB). The continuous relationships of CSF and plasma A\u03b242\/A\u03b240 with amyloid PET burden were modeled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most participants were cognitively normal (427 of 491 [87%]) and the mean age was 69.0\u00a0\u00b1\u00a08.8\u00a0years. CSF A\u03b242\/A\u03b240 predicted amyloid PET burden until a relatively high level of amyloid accumulation (69.8 Centiloids), whereas plasma A\u03b242\/A\u03b240 predicted amyloid PET burden until a lower level (33.4 Centiloids).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>CSF A\u03b242\/A\u03b240 predicts the continuous level of amyloid plaque burden over a wider range than plasma A\u03b242\/A\u03b240 and may be useful in AD staging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Cerebrospinal fluid (CSF) amyloid beta (A\u03b2)42\/A\u03b240 predicts continuous amyloid positron emission tomography (PET) values up to a relatively high burden.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma A\u03b242\/A\u03b240 is a comparatively dichotomous measure of brain amyloidosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Models can predict regional amyloid PET burden based on CSF A\u03b242\/A\u03b240.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSF A\u03b242\/A\u03b240 may be useful in staging AD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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