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We examined CU older adults (<jats:italic>n<\/jats:italic>\u00a0=\u00a03287) who completed alternate versions of the C3 approximately 51 days apart. A subset of CU with abnormal amyloid also completed tau positron emission tomography (PET) imaging. C3 initial performance and practice effects were examined in relation to amyloid status and continuous regional tau burden. Initial C3 performance was associated with amyloid status across all participants, and with tau burden in the medial temporal lobe and early cortical regions in CU with abnormal amyloid. Short\u2010term practice effects were associated with reduced tau in these regions in CU with abnormal amyloid, but were not associated with amyloid status. Thus, computerized cognitive testing repeated over a short follow\u2010up period provides additional insights into early Alzheimer's disease processes.<\/jats:p>","DOI":"10.1002\/dad2.12414","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T06:16:29Z","timestamp":1679292989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Computerized cognitive practice effects in relation to amyloid and tau in preclinical Alzheimer's disease: Results from a multi\u2010site cohort"],"prefix":"10.1002","volume":"15","author":[{"given":"Christina B.","family":"Young","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Science Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Mormino","sequence":"additional","affiliation":[{"name":"Department of Neurology and 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