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We examined relationships between biomarkers and a highly granular measure of memory consolidation, retroactive interference (RI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biomarkers of AD pathology were related to RI. Dentate gyrus (DG) and CA3 volume were uniquely associated with RI, whereas CA1 and BA35 volume were related to both RI and overall memory recall. AD pathology was associated with reduced BA35, CA1, and subiculum volume. DG volume and A\u03b2 were independently associated with RI, whereas CA1 volume mediated the relationship between AD pathology and RI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Integrity of distinct hippocampal subfields demonstrate differential relationships with pathology and memory function, indicating specificity in vulnerability and contribution to different memory processes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12419","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T10:26:31Z","timestamp":1680690391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-3851","authenticated-orcid":false,"given":"Jenna N.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddie","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra S.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Janecek","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake A.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Noche","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina 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University of California  Irvine California USA"},{"name":"Department of Neurology University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California  San Diego California USA"},{"name":"Veterans Affairs San Diego Healthcare System  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Yassa","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California  Irvine California 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