{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:10:54Z","timestamp":1781100654963,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Dementia with Lewy bodies (DLB) is typically characterized by parietal, temporal, and occipital atrophy, but less is known about the newly defined prodromal phases. The objective of this study was to evaluate structural brain alterations in prodromal DLB (p\u2010DLB) as compared to healthy controls (HC) and full\u2010blown dementia (DLB\u2010DEM).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The study included 42 DLB patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a020 p\u2010DLB; <jats:italic>n<\/jats:italic>\u00a0=\u00a022 DLB\u2010DEM) and 27 HC with a standardized neurological assessment and 3\u2010tesla magnetic resonance imaging. Voxel\u2010wise analyses on gray\u2010matter and cortical thickness were implemented to evaluate differences between p\u2010DLB, DLB\u2010DEM, and HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>p\u2010DLB and DLB\u2010DEM exhibited reduced occipital and posterior parieto\u2010temporal volume and thickness, extending from prodromal to dementia stages. Occipital atrophy was more sensitive than insular atrophy in differentiating p\u2010DLB and HC. Occipital atrophy correlated to frontotemporal structural damage increasing from p\u2010DLB to DLB\u2010DEM.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Occipital and posterior\u2010temporal structural alterations are an early signature of the DLB continuum and correlate with a long\u2010distance pattern of atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12462","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T20:11:18Z","timestamp":1700856678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Occipital atrophy signature in prodromal Lewy bodies disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Alice","family":"Galli","sequence":"first","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Neurology Unit, Department of Continuity of Care and Frailty ASST Spedali Civili Brescia University Hospital  Brescia Italy"},{"name":"Laboratory of Digital Neurology and Biosensors University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-6606","authenticated-orcid":false,"given":"Andrea","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Neurology Unit, Department of Continuity of Care and Frailty ASST Spedali Civili Brescia University Hospital  Brescia Italy"},{"name":"Laboratory of Digital Neurology and Biosensors University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Chiarini","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Giunta","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Corbo","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit Department of Molecular and Translational Medicine University of Brescia and ASST Spedali Civili Hospital  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Tirloni","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Neurology Unit, Department of Continuity of Care and Frailty ASST Spedali Civili Brescia University Hospital  Brescia 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Biosensors University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Zatti","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Clinical and Experimental Sciences University of Brescia  Brescia Italy"},{"name":"Neurology Unit, Department of Continuity of Care and Frailty ASST Spedali Civili Brescia University Hospital  Brescia Italy"},{"name":"Laboratory of Digital Neurology and Biosensors University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"Neurology 5 and Neuropathology Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan 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