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These biomarkers have been grouped in an unbiased research framework, the amyloid (A\u03b2), tau, and neurodegeneration (AT[N]) biomarker system to aid patients\u2019 early diagnosis and stratification. Metrological approaches relying on mass spectrometry have been used for the development of reference materials and reference measurement procedures. Despite their excellent performances as clinical tools, fluid biomarkers often present an important between\u2010laboratory variation. Standardization efforts were carried out on the biomarkers currently included in the AT(N) classification system, involving the collaboration of national metrology institutes, clinicians, researchers, and in vitro diagnostic providers. This article provides an overview of current activities towards standardization. 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