{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:52:13Z","timestamp":1788245533407,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Age\u2010related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects &gt;\u00a064 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We found that cochlear dysfunction, measured by DPOAEs\u2014and not by conventional audiometry\u2014was associated with Clinical Dementia Rating Sum of Boxes (CDR\u2010SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40\u00a0dB) and normal hearing (&lt;25\u00a0dB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings suggest that DPOAEs may be a non\u2010invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.12467","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T01:38:51Z","timestamp":1706837931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2443-8683","authenticated-orcid":false,"given":"Vicente","family":"Medel","sequence":"first","affiliation":[{"name":"Departamento de Neurociencia Facultad de Medicina Universidad de Chile  Santiago Chile"},{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Ib\u00e1\u00f1ez  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Delano","sequence":"additional","affiliation":[{"name":"Departamento de Neurociencia Facultad de Medicina Universidad de Chile  Santiago Chile"},{"name":"Servicio Otorrinolaringolog\u00eda Hospital Cl\u00ednico de la Universidad de Chile  Santiago Chile"},{"name":"Advanced Center for Electrical and Electronical Engineer (AC3E)  Valpara\u00edso Chile"},{"name":"Biomedical Neuroscience Institute (BNI) Facultad de Medicina Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chama","family":"Belkhiria","sequence":"additional","affiliation":[{"name":"Departamento de Neurociencia Facultad de Medicina Universidad de Chile  Santiago 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