{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:33:02Z","timestamp":1775788382506,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We investigated whether mortality in memory clinic patients changed due to coronavirus disease 2019 (COVID\u201019) pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We included patients from the Amsterdam Dementia Cohort: (1) <jats:italic>n<\/jats:italic>\u00a0=\u00a0923 pandemic patients (baseline visit: 2017\u20132018, follow\u2010up: until 2021), and (2) <jats:italic>n<\/jats:italic>\u00a0=\u00a0830 historical control patients (baseline visit: 2015\u20132016, follow\u2010up: until 2019). Groups were well\u2010balanced. We compared mortality during pandemic with historical control patients using Cox regression. Differences in cause of death between groups were explored using Fisher's exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Pandemic patients had a higher risk of mortality than historical control patients (hazard ratio [HR] [95% confidence interval {CI}]\u00a0=\u00a01.34 [1.05\u20131.70]). Stratified for syndrome diagnosis, the effect remained significant in dementia patients (HR [95% CI]\u00a0=\u00a01.35 [1.03\u20131.78]). Excluding patients who died of COVID\u201019\u2010infection, the higher mortality risk in pandemic patients attenuated (HR [95% CI]\u00a0=\u00a01.24 [0.97\u20131.58]). Only the difference in cause of death between pandemic patients and historical control patients for death to COVID\u201019\u2010infection (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Memory clinic patients had increased mortality risk during COVID\u201019 compared to historical control patients, attributable to dementia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We investigated if mortality rates in memory clinic patients changed due to COVID\u201019 pandemic.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We included patients along the cognitive continuum, including SCD, MCI, and dementia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We used a well\u2010balanced historical control group.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Memory clinic patients had higher risk for mortality during COVID\u201019 lockdown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our results indicate that excess mortality is mainly caused by death to COVID\u201019 infection.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12541","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:53:38Z","timestamp":1706489618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of COVID\u201019 pandemic on mortality rate in memory clinic patients"],"prefix":"10.1002","volume":"16","author":[{"given":"Els D.","family":"Bakker","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6919-8340","authenticated-orcid":false,"given":"Ingrid S.","family":"van Maurik","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"},{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam Epidemiology and Data Science  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Methodology  Amsterdam The Netherlands"},{"name":"Northwest Academy Northwest Clinics Alkmaar  Alkmaar The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa D.","family":"Zwan","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freek","family":"Gillissen","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter J.","family":"van der Veere","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"},{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam Epidemiology and Data Science  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Methodology  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke H.","family":"Bouwman","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolande A. 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