{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:06:28Z","timestamp":1789038388808,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We aimed to evaluate informal caregivers\u2019 attitudes toward undergoing and future implementation of blood\u2010based biomarkers (BBBM) testing for Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We explored caregivers\u2019 perspectives, by combining an online survey (<jats:italic>n<\/jats:italic>\u00a0=\u00a0107) with a subsequent focus group (<jats:italic>n<\/jats:italic>\u00a0=\u00a07). We used descriptive statistics and thematic content analysis to identify common themes in answers to open\u2010ended survey questions and focus group data.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Most caregivers (72.0%) favored BBBM for AD diagnosis. Provided with hypothetical scenarios, confidence in a normal result decreased significantly if experienced symptoms were more severe (mild: 78.5%\u00a0vs. severe: 48.6%). Caregivers\u2019 attitudes toward BBBM for screening purposes significantly improved with prospect of treatment (53.3%\u00a0vs. 92.5%). Concerns toward BBBM testing included treatment unavailability, increased\/prolonged distress, and AD\u2010related stigma. Potential benefits were actionability, explanation for symptoms, and opportunities for better care and future treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Emerging AD treatment and reduction of AD\u2010related stigma could profoundly increase public interest in BBBM testing for AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Most informal caregivers would want blood\u2010based biomarker (BBBM) testing for Alzheimer's disease (AD) diagnosis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Perceived (dis)advantages were related to diagnosing AD early.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>With severe symptoms, there was less confidence in normal BBBM results.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Treatment availability would significantly increase interest in BBBM testing for AD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Informal caregivers showed uncertainty regarding the meaning of the term \u201cAD.\u201d<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12549","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T08:28:41Z","timestamp":1708072121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Caregivers\u2019 attitudes toward blood\u2010based biomarker testing for Alzheimer's disease"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3116-7789","authenticated-orcid":false,"given":"Katharina","family":"Bolsewig","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Neurochemistry Laboratory Amsterdam Neuroscience Amsterdam UMC VU University  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"Blok","sequence":"additional","affiliation":[{"name":"Alzheimer Nederland  Amersfoort the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-4243","authenticated-orcid":false,"given":"Eline A. J.","family":"Willemse","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Neurochemistry Laboratory Amsterdam Neuroscience Amsterdam UMC VU University  Amsterdam the Netherlands"},{"name":"Department of Neurology Multiple Sclerosis Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel Departments of Biomedicine and Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-0823","authenticated-orcid":false,"given":"Rob B. M. 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A.","family":"Smets","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Amsterdam Public Health Research Institute University of Amsterdam Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0837","authenticated-orcid":false,"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Neurochemistry Laboratory Amsterdam Neuroscience Amsterdam UMC VU University  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-7938","authenticated-orcid":false,"given":"Leonie N. 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