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Participants\u2019 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0226) mean age was 70.9 years (SD\u00a0=\u00a00.4). CSF concentrations of amyloid beta (A\u03b2)1\u201042, total tau (t\u2010tau), phosphorylated tau (p\u2010tau), neurogranin, and neurofilament light, and volumes of hippocampus, amygdala, total basal forebrain (TBF), and cortical thickness were measured. Linear associations between CSF biomarkers and MRI measures were investigated. In A\u03b21\u201042 positives, higher t\u2010tau and p\u2010tau were associated with smaller hippocampus (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and amygdala (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). In A\u03b21\u201042 negatives, higher t\u2010tau, p\u2010tau, and neurogranin were associated with larger TBF volume (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). No associations were observed between the CSF biomarkers and an AD signature score of cortical thickness. AD\u2010specific biomarkers in cognitively healthy 70\u2010year\u2010olds may be related to TBF, hippocampus, and amygdala. Lack of association with cortical thickness might be due to early stage of disease.<\/jats:p>","DOI":"10.1002\/dad2.12556","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T05:24:24Z","timestamp":1708665864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of CSF biomarkers with MRI brain changes in Alzheimer's disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Nazib M","family":"Seidu","sequence":"first","affiliation":[{"name":"Neuropsychiatric Epidemiology (EPINEP) Centre for Ageing and Health (AGECAP) Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Kern","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology (EPINEP) Centre for Ageing and Health (AGECAP) Institute of Neuroscience and 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