{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:47:27Z","timestamp":1785890847513,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008494","name":"Vontobel-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008494","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Female sex is associated with increased [18F]\u2010flortaucipir signal, which may be affected by amyloid pathology, age, and off\u2010target binding in skull and meninges.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In this cross\u2010sectional study comprising 52 females and 52 matched males, we examined sex\u2010related differences in regional tau\u2010positron emission tomography (PET) with and without considering off\u2010target binding. We assessed the respective contributions of sex, age, amyloid\u2010PET burden, and off\u2010target binding to tau\u2010PET signal. We explored associations between age at menopause and hormone replacement therapy (HRT) use with regional tau\u2010PET signals.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Female sex was associated with increased regional tau both independently and interactively with amyloid, but amyloid\u2010independent associations were largely reduced when controlling for off\u2010target binding. Age but not age*sex interactions explained a small but significant amount of tau\u2010PET signal in temporoparietal regions. Considering the sample size and limited range of amyloid\u2010PET burden, no clear associations between regional tau\u2010PET signals and age at menopause or HRT use could be found.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Female sex is associated with increased [18F]\u2010flortaucipir signal mainly through its interaction with amyloid.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12565","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T02:08:34Z","timestamp":1709863714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Explaining variability in early stages of [18F]\u2010flortaucipir tau\u2010PET binding: Focus on sex differences"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-537X","authenticated-orcid":false,"given":"Dario","family":"Bachmann","sequence":"first","affiliation":[{"name":"Institute for 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