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We aimed to investigate this relationship using the data from the Framingham Heart Study (FHS). We conducted association analysis, partial correlation analysis, and causal dose\u2013response curves using blood biomarkers and other data from 793 middle\u2010aged participants (\u2264 60 years) from the FHS Offspring Cohort. The results revealed associations of adiponectin and fasting blood glucose with midlife memory change, along with a U\u2010shaped relationship of high\u2010density lipoprotein cholesterol with memory change. No significant associations were found for the other blood biomarkers (e.g., amyloid beta protein 42) with memory change. To our knowledge, this is the first sex\u2010specific network analysis of blood biomarkers related to midlife memory change in a prospective cohort study. 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