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This study aimed to identify cognitive progression subtypes and examine their correlation with clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Participants of this study were recruited from the Framingham Heart Study. The Subtype and Stage Inference (SuStaIn) method was used to identify cognitive progression subtypes based on eight cognitive domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Three cognitive progression subtypes were identified, including verbal learning (Subtype 1), abstract reasoning (Subtype 2), and visual memory (Subtype 3). These subtypes represent different domains of cognitive decline during the progression of AD. Significant differences in age of onset among the different subtypes were also observed. A higher SuStaIn stage was significantly associated with increased mortality risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>This study provides a characterization of AD heterogeneity in cognitive progression, emphasizing the importance of developing personalized approaches for risk stratification and intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We used the Subtype and Stage Inference (SuStaIn) method to identify three cognitive progression subtypes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Different subtypes have significant variations in age of onset.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Higher stages of progression are associated with increased mortality risk.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12574","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T03:29:35Z","timestamp":1710991775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring cognitive progression subtypes in the Framingham Heart Study"],"prefix":"10.1002","volume":"16","author":[{"given":"Huitong","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"The Framingham Heart Study Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander P.","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cody","family":"Karjadi","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"The Framingham Heart Study Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting F. 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