{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:01:51Z","timestamp":1760403711868,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971577","82271936"],"award-info":[{"award-number":["81971577","82271936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The distribution of voxel\u2010 and connection\u2010based white matter hyperintensity (WMH) patterns in early\u2010onset Alzheimer's disease (EOAD) and late\u2010onset Alzheimer's disease (LOAD), as well as factors associated with these patterns, remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We analyzed the WMH distribution patterns in EOAD and LOAD at the voxel and connection levels, each compared with their age\u2010matched cognitively unimpaired participants. Linear regression assessed the independent effects of amyloid and vascular risk factors on WMH distribution patterns in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>Patients with<\/jats:bold> EOAD showed increased WMH burden in the posterior region at the voxel level, and in occipital region tracts and visual network at the connection level, compared to controls. LOAD exhibited extensive involvement across various brain areas in both levels. Amyloid accumulation was associated WMH distribution in the early\u2010onset group, whereas the late\u2010onset group demonstrated associations with both amyloid and vascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>EOAD showed posterior\u2010focused WMH distribution pattern, whereas LOAD was with a wider distribution. Amyloid accumulation was associated with connection\u2010based WMH patterns in both early\u2010onset and late\u2010onset\u00a0groups, with additional independent effects of vascular risk factors in late\u2010onset group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list>\n<jats:list-item><jats:p>Both early\u2010onset Alzheimer's disease (EOAD) and late\u2010onset AD (LOAD) showed increased white matter hyperintensity (WMH) volume compared with their age\u2010matched cognitively unimpaired participants.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>EOAD and LOAD exhibited distinct patterns of WMH distribution, with EOAD showing a posterior\u2010focused pattern and LOAD displaying a wider distribution across both voxel\u2010 and connection\u2010based levels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In both EOAD and LOAD, amyloid accumulation was associated with connection\u2010based WMH patterns, with additional independent effects of vascular risk factors observed in LOAD.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12585","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T05:14:19Z","timestamp":1713762859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinct patterns of voxel\u2010 and connection\u2010based white matter hyperintensity distribution and associated factors in early\u2010onset and late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2084-203X","authenticated-orcid":false,"given":"Hui","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Clinical Neurosciences University of Cambridge  Cambridge 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