{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:12:02Z","timestamp":1791573122870,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00155"],"award-info":[{"award-number":["PI19\/00155"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00071"],"award-info":[{"award-number":["PI22\/00071"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Brain glucose hypometabolism is a preclinical feature of Alzheimer's disease (AD). Dietary omega\u20103 fatty acids promote brain glucose metabolism, but clinical research is incipient. Circulating omega\u20103s objectively reflect their dietary intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This was a cross\u2010sectional study in 320 cognitively unimpaired participants at increased risk of AD dementia. Using lipidomics, we determined blood docosahexaenoic (DHA) and alpha\u2010linolenic (ALA) acid levels (omega\u20103s from marine and plant origin, respectively). We assessed brain glucose metabolism using [18\u2010F]\u2010fluorodeoxyglucose (FDG) positron emission tomography (PET).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Blood ALA directly related to FDG uptake in brain areas known to be affected in AD. Stronger associations were observed in apolipoprotein E \u03b54 carriers and homozygotes. For DHA, significant direct associations were restricted to amyloid beta\u2013positive tau\u2010positive participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Blood omega\u20103 directly relate to preserved glucose metabolism in AD\u2010vulnerable brain regions in individuals at increased risk of AD dementia. This adds to the benefits of omega\u20103 supplementation in the preclinical stage of AD dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Blood omega\u20103s were related to brain glucose uptake in participants at risk of Alzheimer's disease (AD) dementia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Complementary associations were observed for omega\u20103 from marine and plant sources.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Foods rich in omega\u20103 might be useful in early features of AD.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12596","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T05:15:23Z","timestamp":1720156523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Omega\u20103 blood biomarkers relate to brain glucose uptake in individuals at risk of Alzheimer's disease dementia"],"prefix":"10.1002","volume":"16","author":[{"given":"Iolanda","family":"L\u00e1zaro","sequence":"first","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Grau\u2010Rivera","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) Instituto de Salud Carlos III  Madrid 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