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We assessed this modality in a predominantly amyloid\u2010negative neurodegenerative condition, Parkinson's disease (PD), and hypothesized that early\u2010phase <jats:sup>18<\/jats:sup>F\u2010florbetaben (eFBB) uptake would reproduce characteristic hypometabolism and hypoperfusion patterns associated with cognitive decline in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>One hundred fifteen PD patients across the spectrum of cognitive impairment underwent dual\u2010phase A\u03b2 PET, structural and arterial spin labeling (ASL) magnetic resonance imaging (MRI), and neuropsychological assessments. Multiple linear regression models compared eFBB uptake to cognitive performance and ASL MRI perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Reduced eFBB uptake was associated with cognitive performance in brain regions previously linked to hypometabolism\u2010associated cognitive decline in PD, independent of amyloid status. Furthermore, eFBB uptake correlated with cerebral perfusion across widespread regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>EFBB uptake is a potential surrogate measure for cerebral perfusion\/metabolism. A dual\u2010phase PET imaging approach may serve as a clinical tool for assessing cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Images taken at amyloid beta (A\u03b2) positron emission tomography tracer injection may reflect brain perfusion and metabolism.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Parkinson's disease (PD) is a predominantly amyloid\u2010negative condition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Early\u2010phase florbetaben (eFBB) in PD was associated with cognitive performance.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>eFBB uptake reflects hypometabolism\u2010related cognitive decline in PD.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>eFBB correlated with arterial spin labeling magnetic resonance imaging measured cerebral perfusion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>eFBB distinguished dementia from normal cognition and mild cognitive impairment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Findings were independent of late\u2010phase A\u03b2 burden.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Thus, eFBB may serve as a surrogate measure for brain metabolism\/perfusion.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12601","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T05:36:09Z","timestamp":1719034569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early\u2010phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease"],"prefix":"10.1002","volume":"16","author":[{"given":"William W. 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