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We aimed to profile PD cognitive subtypes at risk of dementia based on their rate of cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Latent class mixed models stratified subtypes in Parkinson's Progression Markers Initiative (PPMI) (<jats:italic>N\u00a0<\/jats:italic>=\u00a0770) and ICICLE\u2010PD (<jats:italic>N\u00a0<\/jats:italic>=\u00a0212) datasets based on their decline in the Montreal Cognitive Assessment over at least 4 years. Baseline demographic and cognitive data at diagnosis were compared between subtypes to determine their clinical profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four subtypes were identified: two with stable cognition, one with steady decline, and one with rapid decline. Performance on Judgement of Line Orientation, but not category fluency, was associated with a steady decline in the PPMI dataset, and deficits in category fluency, but not visuospatial function, were associated with a steady decline in the ICICLE\u2010PD dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>People with PD susceptible to cognitive decline demonstrate unique clinical profiles at diagnosis, although this differed between cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Four cognitive subtypes were revealed in two Parkinson's disease samples.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Unique profiles of cognitive impairment were related to cognitive decline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Judgement of Line Orientation\/category fluency predictive of steady decline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Global deficits related to rapid cognitive decline and increased dementia risk.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12625","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:14:24Z","timestamp":1722842064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Profiling people with Parkinson's disease at risk of cognitive decline: Insights from PPMI and ICICLE\u2010PD data"],"prefix":"10.1002","volume":"16","author":[{"given":"Dana","family":"Pourzinal","sequence":"first","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael A.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University Newcastle  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Yarnall","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University Newcastle  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline H.","family":"Williams\u2010Gray","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience John van Geest Centre for Brain Repair University of Cambridge  Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience John van Geest Centre for Brain Repair University of Cambridge  Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"McMahon","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Faculty of Health Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland Centre for Clinical Research  Herston Queensland Australia"},{"name":"Department of Neurology Royal Brisbane &amp; 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