{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:32:33Z","timestamp":1791149553864,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>In a 5\u2010year follow\u2010up study, we investigated the enduring effects of cognitive training on older adults with mild cognitive impairment (MCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A randomized controlled single\u2010blind trial involved 145 older adults with MCI, assigned to cognitive training (MEMO+), an active control psychosocial intervention, or a no\u2010contact condition. Five\u2010year effects were measured on immediate and delayed memory recall, the Montreal Cognitive Assessment screening test (MoCA), self\u2010reported strategy use, and daily living difficulties.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>At follow\u2010up, participants who received cognitive training showed a smaller decline in delayed memory and maintained MoCA scores, contrasting with greater declines in the control groups. Cognitive training participants outperformed controls in both delayed memory and MoCA scores at the 5\u2010year time point. No significant group differences were observed in self\u2010reported strategy use or difficulties in daily living.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Cognitive training provides long\u2010term benefits by mitigating memory decline and slowing clinical symptom progression in older adults with MCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Cognitive training reduced the 5\u2010year memory decline of persons with MCI.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cognitive training also reduced decline on the Montreal Cognitive Assessment (MoCA).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>No intervention effect was found on strategy use or activities of daily living.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12626","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:27:06Z","timestamp":1725611226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Five\u2010year effects of cognitive training in individuals with mild cognitive impairment"],"prefix":"10.1002","volume":"16","author":[{"given":"Sylvie","family":"Belleville","sequence":"first","affiliation":[{"name":"Research Centre Institut universitaire de g\u00e9riatrie de Montr\u00e9al  Montreal Canada"},{"name":"Universit\u00e9 de Montr\u00e9al  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Research Centre Institut universitaire de g\u00e9riatrie de Montr\u00e9al  Montreal 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