{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:30:09Z","timestamp":1760401809334,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We aimed to determine the effect of years of schooling (YoS) and age on the Mexican adaptation of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD\u2010MX) scores in preclinical carriers group (PCG) and non\u2010carriers group (NCG) of the <jats:italic>APP<\/jats:italic><jats:sub>V717I<\/jats:sub> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We included 39 first\u2010degree Mexican relatives of <jats:italic>APP<\/jats:italic><jats:sub>V717I<\/jats:sub> carriers (PCG\u00a0=\u00a015; NCG\u00a0=\u00a024). We report eight CERAD\u2010MX tasks: Mini\u2010Mental State Examination (MMSE), Word List Learning (WLL), Delayed Recall (WLD) and Recognition (WLR), Constructional Praxis Copy (CPC) and Recall (CPR), Semantic Verbal Fluency (SVF), and Verbal Boston Naming (VBN), comparing both groups\u2019 performance and simulating new samples\u2019 random vectors by inverse transform sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>PCG and NCG performed similarly on CERAD\u2010MX. In both groups, YoS and age influence all <jats:italic>z<\/jats:italic> scores. A positive age effect resulted for PCG on CPC and SVF; for the NCG on MMSE, SVF, and VBN.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>All tasks are influenced by YoS. Higher YoS\/younger age or YoS\/older age interactions affected different tasks, suggesting that YoS confounds outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Years of schooling (YoS) and age affect the Mexican adaptation of the Consortium to Establish a Registry for Alzheimer's Disease scores of <jats:italic>APP<\/jats:italic><jats:sub>V717I<\/jats:sub> preclinical carriers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Preclinical carriers underperformed non\u2010carriers on Constructional Praxis Recall.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Fewer YoS emerges as a confounding variable when detecting cognitive failures.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Younger participants in both groups overperformed the older ones in the Memory tasks.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Randomized data simulation increases statistical power when analyzing rare diseases.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12631","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T21:35:01Z","timestamp":1724276101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of years of schooling and age on CERAD\u2010MX performance in Mexican preclinical carriers of the <i>APP<\/i><sub>V717I<\/sub> mutation: Randomized data simulation"],"prefix":"10.1002","volume":"16","author":[{"given":"Ang\u00e9lica","family":"Zuno\u2010Reyes","sequence":"first","affiliation":[{"name":"Instituto de Neurociencias CUCBA Universidad de Guadalajara  Jalisco M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"P\u00e9rez\u2010Rubio","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias CUCBA Universidad de Guadalajara  Jalisco M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn Alonso","family":"Flores\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Matem\u00e1ticas, CIMAT  Guanajuato M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Jauregui","family":"Torres","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Matem\u00e1ticas, CIMAT  Guanajuato M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Dumois\u2010Petersen","sequence":"additional","affiliation":[{"name":"Laboratorio de Ciencias Cl\u00ednicas CuValles, Universidad de Guadalajara  Jalisco M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Figuera","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, CIBO\u2010IMSS &amp; Doctorado en Gen\u00e9tica Humana CUCS\u2010Universidad de Guadalajara  Jalisco M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Ringman","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Research Center Department of Neurology Keck School of Medicine at USC  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-9960","authenticated-orcid":false,"given":"Esmeralda","family":"Matute","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias CUCBA Universidad de Guadalajara  Jalisco M\u00e9xico"},{"name":"Departamento de Estudios en Educaci\u00f3n CUCSH, Universidad de Guadalajara  Jalisco M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000507"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12788"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000303973.71803.81"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1133"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001114\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043754"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12773"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20104580(93)90099\u2010w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313541"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.10.039"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230026"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010122110"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acad009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.43.11.2412\u2010a"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000118082"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.39.9.1159"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4851"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.33588\/rn.4511.2007086"},{"key":"e_1_2_9_21_1","first-page":"303","article-title":"Introducci\u00f3n al Estudio del Espa\u00f1ol desde una Perspectiva Multidisciplinaria","author":"Leal Carretero F","year":"2003","journal-title":"Universidad de Guadalajara"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.112.1.155"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201050625\u20104_10"},{"volume-title":"R: A Language and Environment for Statistical Computing","year":"2017","author":"Core Team R","key":"e_1_2_9_24_1"},{"key":"e_1_2_9_25_1","unstructured":"RStudio Team. (2020).RStudio: Integrated development environment for R. Boston MA: RStudio PBC.http:\/\/www.rstudio.com\/"},{"volume-title":"Python Reference Manual","year":"1995","author":"Van Rossum G","key":"e_1_2_9_26_1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180078"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.12.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2021.05.005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040775\u2010z"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704101094"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_33_1","first-page":"23","volume-title":"International Handbook of Cross\u2010Cultural Neuropsychology","author":"Ardila A","year":"2007"},{"volume-title":"Censo de Poblaci\u00f3n y Vivienda 2020","year":"2021","author":"Estad\u00edstica InstitutoNacionalde","key":"e_1_2_9_34_1"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt59"},{"volume-title":"Neuropsychological Assessment","year":"2004","author":"Lezak MD","key":"e_1_2_9_36_1"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010psych\u2010113011\u2010143750"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/13825580902912739"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12925"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.25.5.680.14579"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925564"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.42.8.1445"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.2.309"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.8.661"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103940(95)12046\u20107"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593\u201010"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.12631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T10:52:18Z","timestamp":1760352738000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.12631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/dad2.12631"],"URL":"https:\/\/doi.org\/10.1002\/dad2.12631","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"type":"print","value":"2352-8729"},{"type":"electronic","value":"2352-8729"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12631"}}