{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:23:50Z","timestamp":1784543030890,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>We tested associations between two retinal measures (optic disc pallor, peripapillary retinal nerve fiber layer [pRNFL] thickness) and four magnetic resonance imaging markers of cerebral small vessel disease (SVD; lacunes, microbleeds, white matter hyperintensities, and enlarged perivascular spaces [ePVSs]).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We used PallorMetrics to quantify optic disc pallor from fundus photographs, and pRNFL thickness from optical coherence tomography scans. Linear and logistic regression assessed relationships between retinal measures and SVD markers. Participants (<jats:italic>N<\/jats:italic>\u00a0=\u00a0108, mean age 51.6) were from the PREVENT Dementia study.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Global optic disc pallor was linked to ePVSs in the basal ganglia in both left (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.12, standard error [SE]\u00a0=\u00a00.05, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and right eyes (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.13, SE\u00a0=\u00a00.05, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Associations were also noted in different disc sectors. No pRNFL associations with SVD markers were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Optic disc pallor correlated with ePVSs in the basal ganglia, suggesting retinal examination may be a useful method to study brain health changes related to SVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Optic disc pallor is linked to enlarged perivascular spaces in basal ganglia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>There is no association between peripapillary retinal nerve fiber layer thickness and cerebral small vessel disease markers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Optic disc examination could provide insights into brain health.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The sample included 108 midlife adults from the PREVENT Dementia study.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.12633","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:00:06Z","timestamp":1723100406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT\u2010Dementia study"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-7523","authenticated-orcid":false,"given":"Samuel","family":"Gibbon","sequence":"first","affiliation":[{"name":"Centre for Clinical Brain Sciences Chancellor's Building  Edinburgh UK"},{"name":"Robert O Curle Ophthalmology Suite Institute for Regeneration and Repair  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Psychiatry 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig W.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences Chancellor's Building  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Trucco","sequence":"additional","affiliation":[{"name":"VAMPIRE project, Computing (SSEN) University of Dundee Queen Mother Building  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baljean","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences Chancellor's Building  Edinburgh UK"},{"name":"Robert O Curle Ophthalmology Suite Institute for Regeneration and Repair  Edinburgh UK"},{"name":"Princess Alexandra Eye Pavilion  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Clinical 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