{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:02:19Z","timestamp":1760403739480,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2017424F"],"award-info":[{"award-number":["A2017424F"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201022\u2010972229","AARG\u201021\u2010846504"],"award-info":[{"award-number":["AARG\u201022\u2010972229","AARG\u201021\u2010846504"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Intracranial arteriosclerosis and cerebral amyloid beta (A\u03b2) are both involved in the etiology of Alzheimer's disease (AD) dementia, but the direct link between these two pathologies remains elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In 633 participants (mean age 69 years, 51% women) from the population\u2010based Rotterdam Study, we quantified cerebral A\u03b2 accumulation on amyloid positron emission tomography (PET). We assessed calcification of the intracranial internal carotid (ICAC) and vertebrobasilar arteries (VBAC) as proxies of arteriosclerosis on non\u2010enhanced computed tomography (CT). Using logistic and linear regression, we studied the relationship of presence, burden, and type of calcification with the presence and burden of A\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We found no associations of ICAC [odds ratio (OR): 0.85, 95% confidence interval (CI): 0.43, 1.72] or VBAC [OR: 0.59, CI: 0.26, 1.24] with cerebral A\u03b2. The results did not vary across ICAC subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Intracranial arteriosclerosis was not associated with cerebral A\u03b2, underscoring their independence in the etiology of AD dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Comprehensive assessment of intracranial arteriosclerosis (e.g., including subtypes).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intracranial arteriosclerosis in different arteries and cerebral A\u03b2 are not related.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Arteriosclerosis and A\u03b2 likely influence Alzheimer's disease dementia independently.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70005","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T11:39:06Z","timestamp":1727782746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intracranial arteriosclerosis is not associated with cerebral amyloid deposition"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9369-2297","authenticated-orcid":false,"given":"Anna M.","family":"Streiber","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Neitzel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong Thuy","family":"Nguyen Ho","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike W.","family":"Vernooij","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-2603","authenticated-orcid":false,"given":"Daniel","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2022.12.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040223"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12132"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"e_1_2_8_6_1","first-page":"146","article-title":"Uber eigenartige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer A","year":"1907","journal-title":"All Z Psychiatr"},{"key":"e_1_2_8_7_1","article-title":"Intracranial arteriosclerosis and the risk of dementia: a population\u2010based cohort study","author":"Beukel TC","year":"2023","journal-title":"Alzheimers Dement"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.08.228"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032506"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25380"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003837"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.4339"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00972-2"},{"key":"e_1_2_8_14_1","first-page":"1","article-title":"The Rotterdam Study. 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