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Mo"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) genotype on total hippocampal volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Using neuroimaging data from 37,463 UK Biobank participants, we applied linear regression to quantify the association of age and\n                      <jats:italic>APOE<\/jats:italic>\n                      with hippocampal volume and identified the age when volumes of \u03b52\/\u03b53, \u03b53\/\u03b54, and \u03b54\/\u03b54 carriers significantly deviated from \u03b53\/\u03b53 using generalized additive modeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Total hippocampal volume declined with age, with significant differences by\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype emerging after age 60. \u03b53\/\u03b54 and \u03b54\/\u03b54 carriers displayed reduced volumes from ages 69 and 61, respectively, while \u03b52\/\u03b53 showed delayed decline starting at the age of 76.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      The association of\n                      <jats:italic>APOE<\/jats:italic>\n                      and hippocampal volume is age\u2010dependent, with differences in volumes of \u03b54\/\u03b54 carriers detected as early as age 61. This work underscores the importance of\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype in determining when to begin screening for AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            Apolipoprotein E (\n                            <jats:italic>APOE<\/jats:italic>\n                            ) genotype shows an age\u2010dependent association with total hippocampal volume.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            No association between\n                            <jats:italic>APOE<\/jats:italic>\n                            and total hippocampal volume was detected before age 60.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Accelerated decline was observed in \u03b54\/\u03b54 carriers at age 61 and \u03b53\/\u03b54 at age 69.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Delayed decline was evident in \u03b52\/\u03b53 carriers starting at age 76.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70024","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T23:29:47Z","timestamp":1731713387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hippocampal volumes in UK Biobank are associated with\n                    <i>APOE<\/i>\n                    only in older adults"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0188-2431","authenticated-orcid":false,"given":"Ariya","family":"Chaloemtoem","sequence":"first","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonhoo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey 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