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Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Plasma phosphorylated tau\u2010181 (p\u2010tau181) associations with global cognition and memory are clear, but the link between p\u2010tau181 with other cognitive domains and subjective cognitive decline (SCD) across the clinical spectrum of Alzheimer's disease (AD) and how this association changes based on genetic and demographic factors is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Participants were drawn from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and included 1185 adults &gt;55 years of age with plasma p\u2010tau181 and neuropsychological test data. Linear regression models related plasma p\u2010tau181 to neuropsychological composite and SCD scores with follow\u2010up models examining plasma p\u2010tau181 interactions with cognitive diagnosis, apolipoprotein E <jats:italic>(APOE)<\/jats:italic> \u03b54 carrier status, age, and sex on cognitive outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Higher plasma p\u2010tau181 level was associated with worse memory, executive functioning, and language abilities, and greater informant\u2010reported SCD. Visuospatial abilities and self\u2010report SCD were not associated with plasma p\u2010tau181. Associations were generally stronger in mild cognitive impairment (MCI) or dementia, <jats:italic>APOE<\/jats:italic> \u03b54 carriers, women, and younger participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Higher levels of plasma p\u2010tau181 are associated with worse neuropsychological test performance across multiple cognitive domains; however, these associations vary based on disease stage, genetic risk status, age, and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Greater plasma p\u2010tau181 was associated with lower cognition across most domains.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Associations between p\u2010tau181 and cognition were modified by age and sex.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Level of p\u2010tau181 was more strongly associated with cognition in people with mild cognitive impairment (MCI) and apolipoprotein E (<jats:italic>APOE<\/jats:italic>) \u03b54.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70047","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:57:51Z","timestamp":1734677871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and demographic factors modify the association between plasma phosphorylated tau\u2010181 and cognition"],"prefix":"10.1002","volume":"16","author":[{"given":"Corey J.","family":"Bolton","sequence":"first","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory 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