{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:04Z","timestamp":1786977604535,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016005","name":"Yulgilbar Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Melanopsin is a photopigment with roles in mediating sleep and circadian\u2010related processes, which are often disrupted in Alzheimer's disease (AD). Melanopsin also impacts cognition and synaptogenesis. This study investigated the associations between melanopsin genetic variants, sleep, and markers of brain health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Linear regression analyses examined the relationship of single\u2010nucleotide polymorphisms (SNPs) within the melanopsin gene (\n                      <jats:italic>OPN4<\/jats:italic>\n                      ), with cortical amyloid beta (A\u03b2), cognition, brain volumes, and self\u2010reported sleep traits in cognitively unimpaired older adults. Further analyses assessed whether sleep traits x\n                      <jats:italic>OPN4<\/jats:italic>\n                      SNP interactions were associated with markers of brain health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>OPN4<\/jats:italic>\n                      SNPs rs2355009 and rs3740334 were associated with attention and processing speed and ventricular volume and language, respectively. Furthermore, rs3740334 and rs1079610 showed significant interactions with sleep traits in association with language.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      This study shows associations of\n                      <jats:italic>OPN4<\/jats:italic>\n                      genetic variants with markers of brain health, and suggests that these variants interact with sleep to exacerbate cognitive effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            The relationships between melanopsin gene (\n                            <jats:italic>OPN4<\/jats:italic>\n                            ) variants and markers of brain health were examined cross\u2010sectionally in cognitively unimpaired older individuals.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Variation within\n                            <jats:italic>OPN4<\/jats:italic>\n                            is associated with differences in cognition and ventricular volume.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>rs2355009 and rs3740334 show small\u2013moderate associations with differences in attention and processing speed. Further to this, rs2355009 and rs3740334 were associated with ventricular volumes and language performance, respectively.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The interactions between rs3740334 and rs1079610 and sleep traits also showed small\u2013moderate associations with differences in language performance.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70056","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:12:58Z","timestamp":1737011578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health"],"prefix":"10.1002","volume":"17","author":[{"given":"Ayeisha","family":"Milligan Armstrong","sequence":"first","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Collaborative Genomics and Translation Group, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Curtin Medical School Curtin University, Kent St.  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Collaborative Genomics and Translation Group, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenielle","family":"Porter","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Collaborative Genomics and Translation Group, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Curtin Medical School Curtin University, Kent St.  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dore","sequence":"additional","affiliation":[{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Australian E\u2010Health Research Centre CSIRO  Herston Queensland Australia"},{"name":"Department of Molecular Imaging and Therapy and Centre for PET Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bourgeat","sequence":"additional","affiliation":[{"name":"Australian E\u2010Health Research Centre CSIRO  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"Australian E\u2010Health Research Centre CSIRO  Parkville Victoria Australia"},{"name":"Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"},{"name":"Cogstate Ltd.  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