{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:07:26Z","timestamp":1767834446475,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003417","name":"Deutsche Gesetzliche Unfallversicherung","doi-asserted-by":"publisher","award":["FF\u2010FP295"],"award-info":[{"award-number":["FF\u2010FP295"]}],"id":[{"id":"10.13039\/501100003417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>The aim of the study was to estimate the population\u2010based dementia incidence in Germany over a period of two decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We analyzed data from 4814 participants of the population\u2010based Heinz Nixdorf Recall study (49.8% men, 45\u201375 years at baseline period 2000\u20132003), who have been monitored for the occurrence of cognitive decline and dementia. We calculated the cumulative incidence of dementia and its major subtypes and the incidence rate per 1000 person\u2010years over two decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>During a median follow\u2010up of 18.2 (Q1\u2013Q3: 11.3\u201320.6) years, a total of 298 participants (6.2%) developed dementia (22.1% Alzheimer\u00b4s disease, 23.5% vascular dementia, 15.1% mixed dementia, 9.1% other dementia, 30.2% unspecified). The overall incidence rate was 3.9 per 1000 person\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our study is the only current population\u2010based study in Germany that estimates the incidence of dementia. In order to reduce the high proportion of unspecific dementia diagnoses, diagnostics urgently need to be improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>New data on the incidence of dementia in Germany in participants \u226545 years of age.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Participants have been monitored for dementia incidence over two decades.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The overall incidence in our cohort was 3.9 per 1000 person\u2010years.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Many patients had unspecific dementia diagnoses in their medical records.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Further diagnostic evaluation should be available for all dementia patients.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70061","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:31:27Z","timestamp":1737012687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of dementia in the German Heinz Nixdorf Recall study over 20 years"],"prefix":"10.1002","volume":"17","author":[{"given":"Sara","family":"Schramm","sequence":"first","affiliation":[{"name":"Fliedner University of Applied Sciences D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Rinck","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nela","family":"Krizanovic","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Heinz","family":"J\u00f6ckel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"H\u00fcsing","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Gronewold","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00f6rge","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stang","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"School of Public Health Department of Epidemiology Boston University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Jokisch","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504327"},{"key":"e_1_2_9_3_1","unstructured":"DeutschlG MaierW et al. 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