{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:18:23Z","timestamp":1788873503371,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Blood\u2010based biomarkers seem promising for the diagnosis of Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We performed a systematic review and meta\u2010analysis on the potential of blood phosphorylated Tau181 (p\u2010tau181) to differentiate amyloid\u2010positive (A+) and amyloid\u2010negative (A\u2212) subjects. Two meta\u2010analyses were conducted, showing the mean p\u2010tau values in blood and cerebrospinal fluid (CSF) in the A+ and A\u2212 group, and the second comparing the mean p\u2010tau concentrations in blood and CSF among A+ versus A\u2010 participants, by laboratory assessment method.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Eighteen studies (2764 A+ and 5646 A\u2212 subjects) were included. The single\u2010group meta\u2010analysis showed mean higher blood p\u2010tau181 values in the A+ than in the A\u2212 group. In the head\u2010to\u2010head meta\u2010analysis, blood p\u2010tau reliably differentiated A+ patients from A\u2212 participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Regardless of the laboratory technique, blood p\u2010tau181 reliably differentiates A+ and A\u2212 subjects. Therefore, it might have important applications for early diagnosis and inclusion in clinical trials for AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The role of blood\u2010based biomarkers in discriminating AD patients is still uncertain.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blood p\u2010tau181 distinguishes among amyloid\u2010positive and amyloid\u2010negative subjects.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blood p\u2010tau181 might allow early diagnosis and inclusion in clinical trials.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70068","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:28:09Z","timestamp":1737012489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blood phosphorylated Tau181 reliably differentiates amyloid\u2010positive from amyloid\u2010negative subjects in the Alzheimer's disease continuum: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-6418","authenticated-orcid":false,"given":"Annibale","family":"Antonioni","sequence":"first","affiliation":[{"name":"Doctoral Program in Translational Neurosciences and Neurotechnologies Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"},{"name":"Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"},{"name":"Department of Neuroscience Ferrara University Hospital  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela Maria","family":"Raho","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara 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