{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:12:45Z","timestamp":1784002365307,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019250","name":"John Douglas French Alzheimer's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Plasma amyloid beta<jats:sub>42<\/jats:sub>\/amyloid beta<jats:sub>40<\/jats:sub> (A\u03b2<jats:sub>42<\/jats:sub>\/A\u03b2<jats:sub>40<\/jats:sub>) and phosphorylated tau217 (p\u2010tau217) identify individuals with primary Alzheimer's disease (AD). They may detect AD co\u2010pathology in the setting of other primary neurodegenerative diseases, but this has not been systematically studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We compared the clinical, neuroimaging, and neuropathological associations of plasma A\u03b2<jats:sub>42<\/jats:sub>\/A\u03b2<jats:sub>40<\/jats:sub> (mass spectrometry), p\u2010tau217 (electrochemiluminescence), and neurofilament light ([NfL], single molecule array [Simoa]), as markers of AD co\u2010pathology, in a sporadic frontotemporal dementia (FTD) cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0620).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A\u03b2<jats:sub>42<\/jats:sub>\/A\u03b2<jats:sub>40<\/jats:sub> showed no clinicopathological associations. High p\u2010tau217 was present in amnestic dementia (AmD) presumed to be due to FTD, logopenic primary progressive aphasia (lvPPA), and <jats:italic>APOE\u03b54<\/jats:italic> carriers, and correlated with worse baseline and longitudinal clinical scores, lower hippocampal volumes, and more severe AD co\u2010pathology (Braak Stage). NfL was elevated in all FTD phenotypes, and correlated with clinical scores and frontotemporal brain volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Plasma p\u2010tau217 has clinical, neuroimaging, and neuropathological correlates in sporadic FTD and may identify FTD cases with AD co\u2010pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Alzheimer's disease (AD) features could be identified with plasma phosphorylated tau217 (p\u2010tau217) in frontotemporal lobar degeneration (FTLD).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Plasma p\u2010tau217 is a better discriminator of AD co\u2010pathology and AD\u2010associated features in FTLD than plasma amyloid beta<jats:sub>42<\/jats:sub>\/amyloid beta<jats:sub>40<\/jats:sub> (A\u03b2<jats:sub>42<\/jats:sub>\/A\u03b2<jats:sub>40<\/jats:sub>) and neurofilament light (NfL).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In FTLD, plasma p\u2010tau217, but not A\u03b2<jats:sub>42<\/jats:sub>\/A\u03b2<jats:sub>40<\/jats:sub> or neurofilament light, has phenotypical, neurocognitive, and neuroimaging correlates suggestive of AD co\u2010pathology.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70078","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T02:27:52Z","timestamp":1738204072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical and neuropathological associations of plasma A\u03b2<sub>42<\/sub>\/A\u03b2<sub>40<\/sub>, p\u2010tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders"],"prefix":"10.1002","volume":"17","author":[{"given":"Binita","family":"Rajbanshi","sequence":"first","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Prufer Q C Araujo","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawren","family":"VandeVrede","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Ljubenkov","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Staffaroni","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary W.","family":"Heuer","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argentina","family":"Lario Lago","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana Marisa","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Petrucelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Gendron","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Spina","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology, Memory and Aging Center University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri 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