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However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegeneration and neuroinflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>RPP was cross\u2010sectionally evaluated as a predictor of CSF biomarker levels in a cohort of 310 cognitively unimpaired late\u2010middle\u2010aged adults at risk for Alzheimer's disease. The primary outcomes were CSF levels of \u03b1\u2010Synuclein, glial fibrillary acidic protein, neurofilament light (NfL), soluble triggering receptor expressed in myeloid cells 2, and total tau. Further analyses examined amyloid beta (A\u03b2)42\/A\u03b240, phosphorylated tau 181 (pTau181), and pTau181\/A\u03b24.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>RPP was positively associated with NfL (\u03b2 =\u00a00.006, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.411, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.012, but Bonferroni\u2010corrected <jats:italic>p<\/jats:italic> \u2264\u00a00.006) and not with other CSF biomarkers of neurodegeneration and neuroinflammation investigated in this sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>A high myocardial oxygen demand at rest may be related to neuronal death and axonal degeneration in cognitively unimpaired late\u2010middle\u2010aged adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We explored the relationship between RPP and CSF analytes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Higher RPP was associated with higher NfL but not other measured CSF biomarkers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>HR was positively associated with NfL, whereas SBP was not.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70086","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T14:51:37Z","timestamp":1743087097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4580-5800","authenticated-orcid":false,"given":"Chinenye C.","family":"Odo","sequence":"first","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah R.","family":"Lose","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine L.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital  Madison Wisconsin USA"},{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara B.","family":"Bendlin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"Geriatric Research Education and Clinical Center William S. 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