{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:54:56Z","timestamp":1791406496550,"version":"4.3.3"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"am","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01 AG049050"],"award-info":[{"award-number":["K01 AG049050"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG061788"],"award-info":[{"award-number":["R01 AG061788"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG19771"],"award-info":[{"award-number":["R01 AG19771"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG10133"],"award-info":[{"award-number":["P30 AG10133"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072976"],"award-info":[{"award-number":["P30 AG072976"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CNS\u20100521433"],"award-info":[{"award-number":["CNS\u20100521433"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>The brain age gap estimation (BrainAGE) method uses a machine learning model to generate an age estimate from structural magnetic resonance imaging (MRI) scans. The goal was to study the association of brain age with Alzheimer's disease (AD) imaging and plasma biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>One hundred twenty\u2010three individuals from the Indiana Memory and Aging Study underwent structural MRI, amyloid and tau positron emission tomography (PET), and plasma sampling. The MRI scans were processed using the software program BrainAgeR to receive a \u201cbrain age\u201d estimate. Plasma biomarker concentrations were measured, and partial Pearson correlation models were used to evaluate their relationship with brain age gap (BAG) estimation (BrainAGE\u00a0=\u00a0chronological age \u2013 MRI estimated brain age).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Significant associations between BAG and amyloid and tau levels on PET and in plasma were observed depending on diagnostic categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>These findings suggest that BAG is potentially a biomarker of pathology in AD which can be applied to routine brain imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Novel research that uses an artificial intelligence learning tool to estimate brain age.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Findings suggest that brain age gap is associated with plasma and positron emission tomography Alzheimer's disease (AD) biomarkers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Differential relationships are seen in different stages of disease (preclinical vs. clinical).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Results could play a role in early AD diagnosis and treatment.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70094","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:40:28Z","timestamp":1741736428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between BrainAGE and Alzheimer's disease biomarkers"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7048-4923","authenticated-orcid":false,"given":"Yousaf","family":"Abughofah","sequence":"first","affiliation":[{"name":"Indiana Medical Student Program for Research and Scholarship, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Deardorff","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Vosmeier","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah","family":"Hottle","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Neurology, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desarae","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Center for Neuroimaging Department of Radiology and Imaging Sciences, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana G.","family":"Apostolova","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Neurology, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Brosch","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Neurology, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Clark","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Neurology, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Farlow","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Neurology, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Biostatistics, Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Wang","sequence":"additional","affiliation":[{"name":"Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Psychiatry Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry 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