{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:49:11Z","timestamp":1787914151459,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Identification of early\u2010stage Alzheimer's disease (AD) remains a challenge due to limited specialist availability, diagnostic access, disease awareness, and cultural factors. Blood\u2010based biomarkers (BBBM) could play a critical role in the identification and referral of patients suspected of AD to specialty care. A multidisciplinary AD Biomarker Task Force was convened to evaluate current biomarker use cases, define an optimal biomarker\u2010enabled AD diagnostic care pathway, and understand factors impacting adoption. The Task Force identified opportunities to support biomarker\u2010enabled AD diagnostic care pathway adoption, including streamlining risk assessment and screening by leveraging digital tools, activating primary care providers through education, generating data to expand applicability to diverse populations, and advocating for aligned policies and quality measures. Adoption of BBBMs in the primary care setting will be critical to improve early AD detection. However, challenges to pathway adoption persist and will require action from clinicians, payers, policy makers, and patients to address.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Blood\u2010based biomarkers can streamline the identification of AD in primary care.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Future biomarker\u2010enabled diagnostic care pathways will leverage digital assessments.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Education, data generation, and policy advocacy are vital to encourage BBBM use.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Implementation of AD care pathways requires the activation of diverse stakeholders.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70095","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:14:25Z","timestamp":1741716865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Opportunities to encourage adoption of a biomarker\u2010enabled care pathway for Alzheimer's in primary care"],"prefix":"10.1002","volume":"17","author":[{"given":"Soo","family":"Borson","sequence":"first","affiliation":[{"name":"University of Southern California Keck School of Medicine Alhambra California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoda","family":"Au","sequence":"additional","affiliation":[{"name":"Boston University Chobanian &amp; Avedisian School of Medicine and School of Public Health Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H.","family":"Chodos","sequence":"additional","affiliation":[{"name":"University of California San Francisco School of Medicine San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-4721","authenticated-orcid":false,"given":"Sam","family":"Gandy","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai and James J Peters VA Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1756-7066","authenticated-orcid":false,"given":"Holly","family":"Jain","sequence":"additional","affiliation":[{"name":"Brain Health Leaders Network New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Alagor","sequence":"additional","affiliation":[{"name":"Brain Health Leaders Network New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Cohn","sequence":"additional","affiliation":[{"name":"Brain Health Leaders Network New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana R.","family":"Kerwin","sequence":"additional","affiliation":[{"name":"Kerwin Medical Center LLC Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"Mintzer","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina and Ralph H. Johnson VA Healthcare System Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Monroe","sequence":"additional","affiliation":[{"name":"UsAgainstAlzheimer's Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delecia","family":"Robinson","sequence":"additional","affiliation":[{"name":"EviCore Healthcare Bluffton South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention Wake Forest University School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Wilcock","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine Stark Neurosciences Research Institute Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Alzheimer's Disease Facts and Figures [Internet]","author":"Alzheimer's Association","year":"2024"},{"key":"e_1_2_8_3_1","volume-title":"Alzheimer's Disease and Dementia [Internet]","author":"Centers for Disease Control and Prevention","year":"2024"},{"key":"e_1_2_8_4_1","volume-title":"Medical Tests for Diagnosing Alzheimer's [Internet]","author":"Alzheimer's Association","year":"2024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102023\u20101434"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.89"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12508"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010022\u201000269\u2010x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjhci-2023-100914"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010022\u201007736\u20106"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13886"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/21501319221141178"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000977\u20105"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14184"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000989\u20101"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:39:19Z","timestamp":1760384359000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/dad2.70095"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70095","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70095"}}