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Here we extend this work to midlife women, who commonly experience menopause\u2010related sleep and cognitive problems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>One hundred ninety\u2010four postmenopausal participants underwent a neuropsychological evaluation, 72\u00a0h of wrist actigraphy generating RAR variables, and a blood draw to measure AD biomarkers: phosphorylated tau (p\u2010tau181, p\u2010tau231) and amyloid beta (A\u03b240, A\u03b242).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Lower interdaily stability (IS) and relative amplitude (RA) and higher interdaily variability (IV) and least active 5 h (L5) were associated with worse processing speed, independent of sleep. Adjustment for sleep significantly attenuated the associations of RA with memory. Lower RA was associated with higher p\u2010tau231 level, independent of sleep. Further adjustment for menopause\u2010related factors modestly accounted for the associations between RAR, cognitive measures, and AD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Weaker RAR, particularly RA, was associated with worse cognitive functions, and higher AD biomarkers levels, possibly linking RAR with AD pathology in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Lower rhythm stability and robustness and higher fragmentation were associated with worse processing speed.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lower robustness was associated with higher levels of phosphorylated tau\u2010231.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Menopause factors did not attenuate the association between rest\u2010activity rhythms and cognitive function.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70105","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:56:26Z","timestamp":1744764986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rest\u2010activity rhythm characteristics associated with lower cognitive performance and Alzheimer's disease biomarkers in midlife women"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6615-8854","authenticated-orcid":false,"given":"Alexandra","family":"Paget\u2010Blanc","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Psychology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Smagula","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Neurosurgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Department of Psychology University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Department of Obstetrics and Gynecology University of Illinois at Chicago  Chicago Illinois 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