{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:36:21Z","timestamp":1793723781586,"version":"4.6.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["BCA527734"],"award-info":[{"award-number":["BCA527734"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Mild behavioral impairment (MBI), marked by late\u2010onset persistent neuropsychiatric symptoms (NPS), may signal early dementia risk. While MBI is linked to previously established amyloid\u2010beta (A\u03b2) and tau biomarkers, its association with plasma p\u2010tau217, a promising blood\u2010based biomarker for Alzheimer's disease (AD), remains unexplored. Here, we investigated the association between MBI and plasma p\u2010tau217 in dementia\u2010free individuals from the Alzheimer's Disease Neuroimaging Initiative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>MBI was defined using the Neuropsychiatric Inventory (NPI) data. Linear regression assessed the association between NPS status and continuous p\u2010tau217 levels, while logistic regression modeled the association between NPS status and p\u2010tau217 positivity, using a study\u2010specific cutoff. Models adjusted for age, sex, education, and cognitive diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 101 participants (mean age\u00a0=\u00a072.0\u00a0\u00b1\u00a06.5; 44.6% female), those with MBI had higher plasma p\u2010tau217 levels (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a036.4%; 95% confidence interval [CI]: 2.2\u201382.0,\u00a0\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.04) and higher odds of being p\u2010tau217 positive (odds ratio [OR]\u00a0=\u00a03.06, 95% CI: 1.14\u20138.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) than MBI\u2010 participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings support the role of MBI in AD risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Mild behavioral impairment (MBI) is linked to elevated plasma p\u2010tau217, a specific Alzheimer's disease biomarker.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MBI increases the odds of plasma p\u2010tau217 positivity in dementia\u2010free individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings support MBI as an early indicator for Alzheimer's disease risk.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MBI assessment can improve biomarker\u2010based screening and clinical trial efficiency.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70119","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T23:14:14Z","timestamp":1747869254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exploring the association between mild behavioral impairment and plasma p\u2010tau217: Implications for early detection of Alzheimer's disease"],"prefix":"10.1002","volume":"17","author":[{"given":"Maryam","family":"Ghahremani","sequence":"first","affiliation":[{"name":"Department of Psychiatry Cumming School of Medicine University of Calgary  Calgary Alberta 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