{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:31:47Z","timestamp":1787610707967,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24dk0207070"],"award-info":[{"award-number":["JP24dk0207070"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K18262"],"award-info":[{"award-number":["23K18262"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Previous studies have reported that cerebrospinal fluid (CSF) amyloid beta (A\u03b242\/A\u03b238) performs comparably to A\u03b242\/A\u03b240 in predicting amyloid positron emission tomography (PET) positivity in White cohorts. However, this finding has not been validated in diverse populations. Moreover, the utility of CSF A\u03b238 in diagnosing various neurological diseases has not been fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed CSF A\u03b238, A\u03b240, A\u03b242, phosphorylated tau181, and neurofilament light chain in Japanese research and clinical cohorts with Alzheimer's clinical syndrome (ACS) or non\u2010ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CSF A\u03b242\/A\u03b238 predicted amyloid PET positivity comparably to A\u03b242\/A\u03b240. The levels of CSF A\u03b238 were significantly lower in patients with progressive supranuclear palsy (PSP) and idiopathic normal pressure hydrocephalus (iNPH) than in those with other diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We validated the high diagnostic performance of CSF A\u03b242\/A\u03b238 in Japanese patients with AD. CSF A\u03b238 reduction may be a characteristic feature of PSP and iNPH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The diagnostic value of cerebrospinal fluid (CSF) amyloid beta (A\u03b2)38 was examined in Japanese research and clinical cohorts.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSF A\u03b242\/A\u03b238 and A\u03b242\/A\u03b240 showed comparable performance to detect brain A\u03b2 deposition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSF A\u03b242\/A\u03b238 and A\u03b242\/A\u03b240 discordant group showed a characteristic profile.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CSF A\u03b238 and A\u03b240 were prominently decreased in progressive supranuclear palsy and idiopathic normal pressure hydrocephalus.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70125","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T07:15:21Z","timestamp":1747984521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical utility of CSF A\u03b238 in Japanese research and clinical cohorts"],"prefix":"10.1002","volume":"17","author":[{"given":"Tamao","family":"Tsukie","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics Brain Research Institute Niigata University  Niigata 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