{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:07:05Z","timestamp":1777950425617,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007494","name":"Fondation Plan Alzheimer","doi-asserted-by":"publisher","award":["Alzheimer Plan 2008\u20102012"],"award-info":[{"award-number":["Alzheimer Plan 2008\u20102012"]}],"id":[{"id":"10.13039\/501100007494","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The cognitive and neuroimaging evolution during dementia with Lewy bodies (DLB) from the prodromal phase\u2009(Pro\u2010DLB;\u2009subjective\u2009cognitive impairment [SCI] to mild cognitive impairment\u2009[MCI]) according to amyloid beta (A\u03b2) status is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The decline of Lewy\u2010Memento patients with SCI or MCI was compared according to A\u03b2 status across four groups: Pro\u2010DLB, prodromal Alzheimer's disease (Pro\u2010AD), Pro\u2010DLB+AD, and a group without prodromal DLB and AD (no symptoms [NS]). We observed the evolution of cognitive, functional, quality of life measures, brain volumetry, and metabolism on fluorodeoxyglucose positron emission tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In the Pro\u2010DLB and Pro\u2010DLB+AD groups, A\u03b2+ patients had more cognitive and functional decline than the A\u03b2\u2013 patients. In the Pro\u2010AD and NS groups, A\u03b2+ patients had more functional decline. A\u03b2+ Pro\u2010AD showed a greater volume decline of the brain (left insula).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The presence of amyloid lesions worsens very prodromal DLB patients over time, both cognitively and functionally, but without increasing atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Patients at a very prodromal stage, subjective cognitive impairment or mild cognitive impairment, had a clinical diagnosis of either prodromal Alzheimer's disease (Pro\u2010AD), prodromal dementia with Lewy bodies (Pro\u2010DLB), Pro\u2010DLB+AD, or no diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid beta positive (A\u03b2+) patients had more functional decline, whatever the group.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A\u03b2+ DLB patients (Pro\u2010DLB and Pro\u2010DLB+AD) had more global cognitive (Mini\u2010Mental State Examination) decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A\u03b2+ Pro\u2010AD patients showed a greater volume decline of the left insula.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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