{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:05:15Z","timestamp":1789549515058,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015406","name":"Tianjin Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["18ZXRHSY00210"],"award-info":[{"award-number":["18ZXRHSY00210"]}],"id":[{"id":"10.13039\/501100015406","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>AIM<\/jats:title><jats:p>To investigate associations between cognitive status and retinal parameters in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The population\u2010based Beichen Eye Study (BCES) recruited 5840 older adults from Tianjin, China. Retinal thickness and vessel density (VD) were measured using optical coherence tomography angiography (OCT\/OCTA). Cognitive function was assessed via the Mini\u2010Mental State Examination (MMSE). Participants with gradable images and valid MMSE scores (<jats:italic>n<\/jats:italic>\u00a0=\u00a03606) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Cognitive impairment (CI) was identified in 32.7% of participants. Compared to non\u2010CI individuals, those with CI exhibited reduced average retinal thickness (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) and choroid thickness (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Superficial VD (VD<jats:sub>SVP<\/jats:sub>) was significantly higher in moderate to severe CI compared to mild CI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030). Linear mixed\u2010effects regression demonstrated positive correlations between MMSE scores and retinal parameters (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.518 to 0.530).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Retinal thinning may occur in mild CI, with VD changes as CI progresses. Choroidal thinning is a potential cognitive indicator. OCT\/OCTA, as a non\u2010invasive tool, offers potential for early cognitive disorder screening in aging populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Retinal thinning (average retinal thickness: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) and choroidal thinning (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) are significantly associated with CI in older adults.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A paradoxical increase in VD<jats:sub>SVP<\/jats:sub> was observed in moderate to severe CI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030), suggesting compensatory vascular remodeling.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Choroidal thickness emerges as a robust biomarker for cognitive decline (correlation coefficient range: 0.518 to 0.530).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The large\u2010scale population\u2010based study (<jats:italic>n<\/jats:italic>\u00a0=\u00a05840) was conducted integrating OCT\/OCTA imaging with MMSE cognitive assessments.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The study supports OCT\/OCTA as a noninvasive, cost\u2010effective screening tool for early detection of cognitive disorders in resource\u2010limited settings.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The study highlights vascular risk management (e.g., glycemic control, smoking cessation) as a dual target for retinal and cognitive health.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70147","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T06:29:01Z","timestamp":1753252141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cognitive function correlates with retinal structural and vascular imaging parameters in Chinese older adults"],"prefix":"10.1002","volume":"17","author":[{"given":"Manqiao","family":"Wang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gong","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Eric","family":"Pazo","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Hu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital  Tianjin 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