{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:37:49Z","timestamp":1784615869551,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U2CAG060426\u201003"],"award-info":[{"award-number":["5U2CAG060426\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF\u201022\u2010967786"],"award-info":[{"award-number":["AARF\u201022\u2010967786"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>INTRODUCTION<\/jats:title><jats:p>Remote, smartphone\u2010based cognitive assessments such as the Mobile Toolbox (MTB) may increase the accessibility of Alzheimer's disease (AD) clinical trials. We examined the feasibility of the MTB among cognitively unimpaired (CU) older adults and investigated its associations with standardized in\u2010clinic cognitive testing and amyloid and tau positron emission tomography imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 100 CU older adults self\u2010administered the MTB remotely on their personal devices. Linear regression models correcting for demographics investigated associations of MTB fluid and crystallized cognition composites with in\u2010clinic Preclinical Alzheimer's Cognitive Composite\u20105 (PACC\u20105) scores, global amyloid\u2010beta burden and tau deposition in the medial\u2010temporal lobe and neocortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Most participants completed the MTB without requiring assistance (81%) or reminders (61%). MTB fluid cognition scores were positively associated with PACC\u20105 scores and negatively with tau deposition in the medial\u2010temporal lobe and neocortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>These findings suggest that the MTB may provide a feasible approach to capture cognitive processes relevant in preclinical AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>The Mobile Toolbox (MTB) is a remote smartphone\u2010based cognitive assessment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We deployed the MTB in CU older adults with Alzheimer's disease (AD) biomarkers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We show how the MTB may facilitate cognitive assessment in preclinical AD research.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70160","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T13:14:36Z","timestamp":1755609276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Mobile Toolbox for remote, self\u2010administered cognitive assessment in older adults: associations with in\u2010clinic cognitive testing and Alzheimer's disease biomarkers"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-4790","authenticated-orcid":false,"given":"Roos J.","family":"Jutten","sequence":"first","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessa. 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