{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:44:48Z","timestamp":1788918288000,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n Recently two software products (MIMneuro and Syngo.PET) received United States Food and Drug Administration (FDA) clearance for Centiloid analysis, thereby introducing Centiloid scoring to the clinical environment. This study compares Centiloid scores by these clinical products and conventional research methods.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n 18<\/jats:sup>\n F\u2010Florbetapir amyloid positron emission tomography (PET) scans (\n N\u00a0<\/jats:italic>\n =\u00a0252) of cognitively unimpaired elders were processed using both products and using research pipelines based on the Standard Centiloid method (magnetic resonance imaging [MRI]\u2010based spatial normalization).\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Centiloid scores from both products were highly linearly correlated with each other (\n \n r\n 2\u00a0<\/jats:sup>\n <\/jats:italic>\n =\u00a00.942) and with an MRI\u2010based research pipeline having matching regions of interest (MIMneuro:\n \n r\n 2\u00a0<\/jats:sup>\n <\/jats:italic>\n =\u00a00.942, Syngo.PET:\n \n r\n 2\u00a0<\/jats:sup>\n <\/jats:italic>\n =\u00a00.971). However, Centiloid scores often differed by more than 10 Centiloids [CL] between methods, with Centiloid calibrations contributing to their inconsistency.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Although Centiloid analyses were highly correlated, there was considerable variability in individual cases. Other factors not investigated (e.g., radiopharmaceutical, uptake time) could further contribute to variability. Clinicians should use caution when considering thresholds for amyloid positivity in individual cases.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Two newly available clinical software products, which provide rapid and simple Centiloid scoring, are compared to research processing involving both PET and MRI images.<\/jats:p>\n <\/jats:list-item>\n \n Excellent linear correlations were found among the methods.<\/jats:p>\n <\/jats:list-item>\n \n Centiloid scores for individual cases often differed by more than 10CL, which should be taken into consideration in clinical reporting.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dad2.70163","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:50:10Z","timestamp":1754985010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of two clinical Centiloid analysis products for\n 18<\/sup>\n F\u2010florbetapir PET in cognitively unimpaired elders"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-7228","authenticated-orcid":false,"given":"Frank P.","family":"DiFilippo","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine Diagnostics Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Rao","sequence":"additional","affiliation":[{"name":"Lou Ruvo Center for Brain Health Neurological Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-05784-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.268119"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06279-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20181025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.04.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13883"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-024-01919-3"},{"key":"e_1_2_8_10_1","unstructured":"Standardized Centralized Alzheimer's & Related Dementias Neuroimaging (SCAN).https:\/\/scan.naccdata.org\/"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.057"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.150"},{"key":"e_1_2_8_13_1","unstructured":"Centiloid Project\u2014The Global Alzheimer's Alliance Interactive Network.https:\/\/gaain.org\/centiloid\u2010project"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.1353"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.153494"},{"key":"e_1_2_8_16_1","first-page":"84","article-title":"Correlation between two methods of florbetapir PET quantitative analysis","volume":"7","author":"Breault C","year":"2017","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.02.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.266188"},{"key":"e_1_2_8_19_1","first-page":"2553","article-title":"Defining a Centiloid scale threshold predicting long\u2010term progression to dementia in patients attending the memory clinic: an [(18)F] flutemetamol amyloid PET study","volume":"47","author":"Hanseeuw BJ","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14336"}],"container-title":["Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T21:40:35Z","timestamp":1760391635000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/dad2.70163"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70163","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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