{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:06:35Z","timestamp":1760403995664,"version":"build-2065373602"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Physical activity, a key modifiable risk factor for dementia, has been associated with biomarkers of neurodegeneration in the central nervous system, but less is known regarding blood\u2010based biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 739 cognitively healthy participants (aged 50\u201383 years) from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease) completed a battery of online surveys. Self\u2010reported physical activity was assessed based on daily metabolic equivalent, and a blood sample was analyzed for serum neurofilament light chain, serum glial fibrillary acidic protein (GFAP), plasma phosphorylated tau, and genotyped for apolipoprotein E (<jats:italic>APOE<\/jats:italic>) \u03b54.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher self\u2010reported physical activity was significantly associated with lower log\u2010transformed concentrations of GFAP (pg\/mL, <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.022, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) in fully adjusted generalized linear regression models. Subgroup analysis revealed this association was only significant in <jats:italic>APOE<\/jats:italic> \u03b54 non\u2010carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This cross\u2010sectional study provides novel evidence for the association of physical activity with blood\u2010based biomarkers of neurodegeneration, and how <jats:italic>APOE<\/jats:italic> \u03b54 presence modifies this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>HIGHLIGHTS<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>We looked at a large\u2010scale (<jats:italic>n<\/jats:italic>\u00a0=\u00a0739) community cohort of healthy Australians &gt; 50 years of age.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Physical activity (PA) levels were related to blood\u2010based biomarkers of neurodegeneration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Higher PA was associated with lower serum glial fibrillary acidic protein (GFAP).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Apolipoprotein E \u03b54 and PA intensity impacted this association.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This novel finding provides a foundation for targeted physical activity interventions.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/dad2.70166","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T07:17:42Z","timestamp":1755415062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physical activity and blood\u2010based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease)"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-9051","authenticated-orcid":false,"given":"Eddy","family":"Roccati","sequence":"first","affiliation":[{"name":"Wicking 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