{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:48:48Z","timestamp":1787755728309,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Machine learning applied to neuroimaging can help with medical diagnosis and early detection by identifying biomarkers of subtle changes in brain structure and function. The effectiveness of advanced diffusion MRI (dMRI) methods for pre\u2010dementia classification remains largely unexplored, particularly when combined with CSF biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We implemented XGBoost machine learning models to evaluate the classification potential of dMRI parameters (derived using NODDI, C\u2010NODDI, MAP, or SMI), CSF biomarkers of Alzheimer's pathology (Tau, pTau, A\u03b242, A\u03b240), and pairwise dMRI + CSF combinations in distinguishing cognitive normality from mild cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>MAP\u2010RTAP (AUC\u00a0=\u00a00.78) and pTau\/A\u03b242 (AUC\u00a0=\u00a00.76) were the best performing individual biomarkers. Combining C\u2010NDI derived using C\u2010NODDI and A\u03b242\/A\u03b240 achieved the highest performance (AUC\u00a0=\u00a00.84) and accuracy (0.84), while other combinations optimized either sensitivity (0.93) or specificity (0.88).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>dMRI biomarkers demonstrate comparable performance to CSF biomarkers, with notable improvements achieved when combined. This study highlights dMRI's effectiveness for enhancing early AD detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Advanced multishell diffusion MRI provides equivalent performance as CSF biomarkers in classifying MCI<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Combining diffusion MRI and CSF biomarkers improves classification performance<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Statistical diffusion MRI models perform best when used individually to classify MCI<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The pTau\/A\u03b242 ratio outperforms other individual CSF biomarkers in MCI diagnosis<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Biophysical diffusion MRI models achieve the best performance when combined with CSF data<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70182","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T05:22:54Z","timestamp":1757654574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Machine learning diagnosis of mild cognitive impairment using advanced diffusion MRI and CSF biomarkers"],"prefix":"10.1002","volume":"17","author":[{"given":"Alexander 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