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A weakly\u2010supervised clustering algorithm called HYDRA (Heterogeneity through Discriminative Analysis) was applied to volumetric magnetic resonance imaging (MRI) measures to identify distinct subgroups in the population with gait speeds lower than one standard deviation (1SD) above mean.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Three subgroups (Groups A, B, and C) were identified through MRI\u2010based clustering with significant differences in regional brain volumes, gait speeds, and performance on Trail Making (Part\u2010B) and Free and Cued Selective Reminding Tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Based on structural MRI, our results reflect heterogeneity in the population with moderate and slow gait, including those with MCR. Such a data\u2010driven approach could help pave new pathways toward dementia at\u2010risk stratification and have implications for precision health for patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Different patterns of brain atrophy were observed among the people with moderate and slow gait speeds<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Slower gait speeds were associated with substantial cortical atrophy, higher rates of Motoric Cognitive Risk Syndrome (MCR), and worse cognitive performance<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This approach can aid patient stratification at early asymptomatic stages and have implications for precision health.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70197","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:14:30Z","timestamp":1759918470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovering subtypes with imaging signatures in the Motoric Cognitive Risk Syndrome Consortium using weakly supervised clustering"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6368-8509","authenticated-orcid":false,"given":"Bhargav Teja","family":"Nallapu","sequence":"first","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Cognitive Robotics Delft University of Technology Delft Zuid\u2010Holland The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ezzati","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine (UCI), Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.","family":"Blumen","sequence":"additional","affiliation":[{"name":"Department of Neurology Stony Brook University  Stony Brook New York USA"},{"name":"Departments of Medicine Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellen K.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmeline","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neurology Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V G Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology Baby Memorial Hospital  Kozhikode Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Velandai","sequence":"additional","affiliation":[{"name":"National Centre for Healthy Ageing  Frankston Victoria Australia"},{"name":"School of Translational Medicine Monash University  Melbourne Victoria 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