{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:18:48Z","timestamp":1767014328247,"version":"3.48.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NW24J\u201007\u201000064"],"award-info":[{"award-number":["NW24J\u201007\u201000064"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["73305095007"],"award-info":[{"award-number":["73305095007"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10510032120003"],"award-info":[{"award-number":["10510032120003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>To address uncertainty about long\u2010term clinical and economic impacts of an accurate dementia diagnosis, we evaluated the cost\u2010effectiveness of adding amyloid positron emission tomography (PET) to memory clinic workup over 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Inverse probability weighting was used to balance covariates between PET (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0440) and no\u2010PET (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0460) participants from the Amsterdam Dementia Cohort. Time in community following diagnosis, time alive, and costs were combined in cost\u2010effectiveness analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>PET participants lived longer in community (0.26 years, 95% confidence interval [CI]: 0.05 to 0.45) and overall (0.15, CI: 0.02 to 0.27), but did not have statistically different health insurance (\u20ac703, CI: \u22123974 to 5045) or total costs including institutionalization (\u2212\u20ac8258, CI: \u221220,622 to 3377). The probability that PET was cost\u2010effective for extending time in community was 76% at a \u20ac2530 willingness\u2010to\u2010pay threshold. The probability that PET yielded cost savings and was more effective for extending time alive was 90%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Findings in this observational cohort suggest that using amyloid PET in memory clinics may be cost\u2010effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Participants with an amyloid PET in a memory clinic work\u2010up were compared to those without.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The amyloid PET group spent more time in community and alive over 5 years of follow\u2010up.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Amyloid PET had a 76% chance to cost\u2010effectively extend time in community in uncertainty analysis.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70210","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:15:07Z","timestamp":1762280107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term cost\u2010effectiveness of a more accurate diagnostic work\u2010up for dementia"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-6850","authenticated-orcid":false,"given":"Pieter J.","family":"van der Veere","sequence":"first","affiliation":[{"name":"Alzheimer 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Maurik","sequence":"additional","affiliation":[{"name":"Northwest Academy, Northwest Clinics Alkmaar  Alkmaar the Netherland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsmarieke","family":"van de Giessen","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience, Neurodegeneration  Amsterdam the Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Vrije Universiteit Amsterdam, Amsterdam University Medical Center  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argonde C.","family":"van Harten","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology Amsterdam Neuroscience, Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith E.","family":"Bosmans","sequence":"additional","affiliation":[{"name":"Department of Health 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