{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:56:13Z","timestamp":1780379773421,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>There are few studies analyzing cerebrospinal fluid (CSF) in patients with cerebral amyloid angiopathy (CAA). Our goal was to compare blood\u2013brain barrier and neurodegeneration markers in CSF in CAA patients with and without hemorrhagic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a retrospective study of patients with CAA (Boston criteria version 2.0) identified from the Aachen Memory Database and from in\u2010hospital admission records, we compared CSF neurodegeneration markers and albumin ratio (a blood\u2013brain barrier permeability marker) in patients with and without hemorrhagic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 371 patients with CAA, 113 patients had hemorrhagic markers (30.5%). Lower amyloid beta (A\u03b2) 42, lower A\u03b240, and higher albumin ratio were independently associated with the presence of hemorrhagic markers and an increasing number of lobar microbleeds. Cortical superficial siderosis and a higher imaging burden of CAA were associated with total tau protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Presence of hemorrhagic markers in CAA patients is associated with lower CSF A\u03b242 and A\u03b240 and higher blood\u2013brain barrier permeability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>HIGHLIGHTS<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>New diagnostic criteria allow for the diagnosis of CAA without hemorrhagic markers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CAA hemorrhagic markers are associated with lower A\u03b242 and A\u03b240 in CSF.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CAA hemorrhagic markers are associated with higher blood\u2013brain barrier permeability.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher imaging burden of CAA is associated with higher total tau protein in CSF.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70221","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T03:49:21Z","timestamp":1763524161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Profiles of blood\u2013brain barrier and neurodegeneration markers in cerebrospinal fluid of patients with cerebral amyloid angiopathy"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3977-7146","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Pinho","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Nikoubashman","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital RWTH Aachen  Aachen Germany"},{"name":"Department of Diagnostic and Interventional Neuroradiology Evangelisches Klinikum Bethel University Hospital OWL of the University Bielefeld  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"},{"name":"JARA Institute of Molecular Neuroscience and Neuroimaging (INM\u201011) Juelich Research Center GmbH and RWTH Aachen University  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"},{"name":"JARA Institute of Molecular Neuroscience and Neuroimaging (INM\u201011) Juelich Research Center GmbH and RWTH Aachen University  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Sofia","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital RWTH Aachen  Aachen Germany"},{"name":"JARA Institute of Molecular Neuroscience and Neuroimaging (INM\u201011) Juelich Research Center GmbH and RWTH Aachen University  J\u00fclich 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