{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:08:39Z","timestamp":1789567719170,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We assessed associations of cancer diagnoses with neuropathology of Alzheimer's disease (AD) and related dementias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We retrieved 2288 cases from the National Alzheimer Coordinating Center (NACC) cohort with available information on cancer diagnoses and neuropathological scoring of Braak stages, Thal amyloid phases, neuritic plaques, TDP\u201043 pathology, and Lewy body pathology. We used Bayesian ordinal regression to assess associations of prevalent or incident cancer diagnoses with global cognition and postmortem neuropathological scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We found extreme evidence (Bayes factor [BF]\u00a0&gt;\u00a02000) that both prevalent and incident cancer diagnoses were associated with better global cognition, strong evidence (BF\u00a0=\u00a026) for an association of a prevalent cancer diagnosis with lower TDP\u201043 pathology, and weak evidence (BF\u00a0=\u00a03.2) for an association with lower Lewy body pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our data suggest that selective survival and biological effects may contribute to the lower risk of dementia in people with a cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>A prevalent diagnosis of cancer was associated with a lower risk of cognitive decline in older individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A prevalent diagnosis of cancer was associated with a lower risk of TDP\u201043 pathology and Lewy body pathology in older individuals.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Effects of cancer on TDP\u201043 pathology were maintained when controlling for degree of cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70222","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:21:19Z","timestamp":1765167679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of cancer with neuropathological markers of Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-3194","authenticated-orcid":false,"given":"Stefan","family":"Teipel","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Rostock\/Greifswald  Rostock Germany"},{"name":"Department of Psychosomatic Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas","family":"Akmatov","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Healthcare Atlas Central Research Institute of Ambulatory Health Care in Germany  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Michalowsky","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Rostock\/Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Junghanss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Clinic for Hematology Oncology and Palliative Care Rostock University Medical Center  Rostock Germany"},{"name":"Comprehensive Cancer Center Mecklenburg\u2010Vorpommern (CCC\u2010MV) Rostock\/Greifswald  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Holstiege","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Healthcare Atlas Central Research Institute of Ambulatory Health Care in Germany  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bohlken","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine Occupational Health and Public Health Faculty of Medicine University of Leipzig  Leipzig 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