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Here, we evaluated the accuracy of NGN in detecting cognitive impairment compared to traditional norms (TN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This multicenter study included\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a02405 participants classified as cognitively normal (CN,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0987) or with mild cognitive impairment (MCI,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01418) using conventional criteria. All participants underwent neuropsychological testing and cerebrospinal fluid Alzheimer's disease (AD) biomarker assessment. We used actuarial neuropsychological criteria to reclassify all participants using TN and NGN. Diagnostic groups were compared on cognitive performance, AD biomarker positivity, and longitudinal cognitive trajectories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Nineteen percent of TN\u2010classified CN participants were diagnosed with MCI by NGN, whereas 3% of TN\u2010classified MCI were identified as CN by NGN. NGN demonstrated stronger associations with neuropsychological performance, AD biomarkers, and progression than TN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>NGN enhance the detection of objective cognitive impairment, with direct implications for clinical practice and research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Next\u2010generation norms (NGN) reclassify one of every five cases from cognitively normal (CN) to mild cognitive impairment (MCI).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This group shows poor cognitive performance and a high prevalence of amyloid \u03b2 positivity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NGN\u2010based diagnosis of MCI predicts cognitive progression on follow\u2010up.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Results indicate that NGN improve the detection of objective cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NGN can inform biomarker use, therapy indication, and clinical trial design.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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