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Within each subtype, we evaluated plasma p\u2010tau217 levels, their association with regional tau PET uptake, differences between cognitively unimpaired (CU) and cognitively impaired (CI) individuals, and relationships to cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four subtypes were identified: limbic, medial temporal lobe (MTL) sparing, posterior, and lateral temporal (l temporal). Plasma p\u2010tau217 was elevated in CI versus CU in limbic, posterior, and l temporal subtypes and strongly associated with tau deposition and cognitive performance. In the MTL\u2010sparing subtype, p\u2010tau217 showed a significant association with tau but no elevation in CI and no relationship to cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings indicate that p\u2010tau217's diagnostic utility varies across AD subtypes, reflecting distinct biological mechanisms not captured by current blood biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma phosphorylated tau (p\u2010tau)217 differentiated cognitively unimpaired from impaired individuals in most subtypes, with the notable limitation of the medial temporal lobe (MTL)\u2010sparing group.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>P\u2010tau217 level was linked to regional tau accumulation as measured by tau positron emission tomography, across all subtypes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The MTL\u2010sparing subtype appeared to be unique, as p\u2010tau217 was not elevated in cognitively impaired individuals, and there was no clear relationship between p\u2010tau217 levels and cognitive performance.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70227","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:11:59Z","timestamp":1764213119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic utility of plasma p\u2010tau217 differs by Alzheimer's disease tau\u2010based subtypes"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3900-9603","authenticated-orcid":false,"given":"Seyed Hani","family":"Hojjati","sequence":"first","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy A.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Radiology Brain Health Imaging Institute Weill Cornell Medicine  New York New York 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